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APC anti-mouse CD41 Antibody

Pricing & Availability
Clone
MWReg30 (See other available formats)
Regulatory Status
RUO
Other Names
Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
MWREG30_APC_010412
Mouse platelets were stained with either anti-mouse CD41 (clone MWReg30) APC (filled histogram) or rat IgG1 APC isotype control (dashed histogram).
  • MWREG30_APC_010412
    Mouse platelets were stained with either anti-mouse CD41 (clone MWReg30) APC (filled histogram) or rat IgG1 APC isotype control (dashed histogram).
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Cat # Size Price Quantity Check Availability Save
133913 25 µg 82€
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133914 100 µg 252€
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Description

CD41, also known as integrin α2b and GPIIb, is a transmembrane glycoprotein that is expressed by platelets and megakaryocytes. It was reported that CD41 is also expressed on hematopoietic progenitors. CD41 associates with CD61 (integrin β3) to form complexes that interact with fibrinogen, fibronectin, von Willebrand factor, and thrombin. CD41 is required for platelet adhesion and aggregation. Defect of CD41 leads to disorders of coagulation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse platelets
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).

Application References

(PubMed link indicates BioLegend citation)
  1. Nieswandt B, et al. 1999. Blood 94:684.
  2. Teeling JL, et al. 2001. Blood 98:1095.
  3. Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
  4. Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
  5. Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
  6. van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
  7. Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
Product Citations
  1. Tang Y, et al. 2023. Am J Hematol. 98:881. PubMed
  2. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  3. de Sousa DMB, et al. 2023. Aging (Albany NY). 15:630. PubMed
  4. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  5. Upadhaya S, et al. 2020. Cell Stem Cell. 27(2):336-345.e4. PubMed
  6. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  7. Fujino T, et al. 2021. Nat Commun. 12:1826. PubMed
  8. Nakamura T, et al. 2022. Thromb Res. 209:80. PubMed
  9. Wang W, et al. 2016. Circ Cardiovasc Genet. 9: 213 - 222. PubMed
  10. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  11. McCabe A, et al. 2020. STAR Protocols. 33(7):2294-305. PubMed
  12. Kobayashi H, et al. 2020. STAR Protoc. 1:100078. PubMed
  13. Yeung AK, et al. 2020. Blood Adv. 4:6204. PubMed
  14. Cordeiro O, et al. 2016. PLoS One. 11: 0151848. PubMed
  15. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
  16. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  17. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  18. Zhang Q, et al. 2016. Sci Transl Med. 8: 349ra101. PubMed
  19. Parker KR, et al. 2020. Cell. 183(1):126-142.e17. PubMed
  20. Yan R, et al. 2021. Cell Death Dis. 12:955. PubMed
  21. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  22. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
  23. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  24. Kobayashi H, et al. 2020. Cell Reports. 28(1):145-158.e9.. PubMed
  25. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  26. Da Q, et al. 2018. Microcirculation. 25:e12457. PubMed
  27. Siddique SM, et al. 2019. Sci Rep. 9:13977. PubMed
  28. Chen W, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2028. PubMed
  29. La Salvia S, et al. 2020. Am J Physiol Renal Physiol. 319:F868. PubMed
  30. Kniewallner KM, et al. 2020. Front Neurosci. 14:129. PubMed
  31. Crescente M, et al. 2020. FASEB J. 34:10027. PubMed
  32. Li H, et al. 2020. J Cell Mol Med. 24:3504. PubMed
  33. Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
  34. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  35. Wuescher LM, et al. 2019. Res Pract Thromb Haemost. 3:704. PubMed
  36. Chen W, et al. 2022. J Thromb Haemost. 20:1451. PubMed
RRID
AB_11125581 (BioLegend Cat. No. 133913)
AB_11125581 (BioLegend Cat. No. 133914)

Antigen Details

Structure
A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
Distribution

Platelets, megakaryocytes, and hematopoietic progenitors

Function
Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Hematopoietic stem and progenitors, Megakaryocytes, Platelets
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.

Gene ID
16399 View all products for this Gene ID
UniProt
View information about CD41 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 03.19.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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