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PE anti-mouse/human CD351 (Fc α/µ receptor) Antibody

Pricing & Availability
Clone
TX61 (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
Fcα/μ receptor, Fcα/μR
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TX61_PE_CD351_Antibody_061219.png
Con-A stimulated C57BL/6 splenocytes (3 days) stained with CD3 APC and CD351 (Fc α/µ receptor) (clone TX61) PE (left) or Mouse IgG1, κ PE isotype control (right).
  • TX61_PE_CD351_Antibody_061219.png
    Con-A stimulated C57BL/6 splenocytes (3 days) stained with CD3 APC and CD351 (Fc α/µ receptor) (clone TX61) PE (left) or Mouse IgG1, κ PE isotype control (right).
See PE spectral data
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137306 200 µg 317€
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Description

Fcα/µ receptor (Fcα/µR), CD351, is a type I transmembrane protein with an Ig-like domain in extracellular portion.  It is a novel Fc receptor for IgM and IgA.  Fcα/µ receptor mRNA has been found in thymus, spleen, liver, kidney, intestines, testes, placenta, and T cell leukemia cell lines.  Fcα/µ receptor protein expression is detected on B cells, macrophages, and activated T cells.  Fcα/µ receptor mediates primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus.   It is involved in the primary stages of the immune response to microbes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
mFcα/µ receptor transfected Ba/F3 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported (for relevant formats) application include: blocking binding of both IgM and IgA to the mFca/µ receptor2.

Application References

(PubMed link indicates BioLegend citation)
  1. Cho Y, et al. 2006. Biochem. Biophys. Res. Commun. 345:474.
  2. Shibuya A, et al. 2006. Springer Semin. Immunopathol. 28:377.
  3. Anguetil F, et al. 2015. J Immunol. 194:3664. PubMed
Product Citations
  1. Biswas S, et al. 2021. Nature. 591:464. PubMed
  2. Anquetil F, et al. 2015. J Immunol. 194:3664. PubMed
  3. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
RRID
AB_10550805 (BioLegend Cat. No. 137306)

Antigen Details

Structure
About 70 kD transmembrane glycoprotein with an Ig-like domain in extracellular portion.
Distribution

B cells, macrophages, and activated T cells.

Function
Mediate primary B lymphocyte endocytosis and involve in the primary stages of the immune response to microbes.
Ligand/Receptor
IgA and IgM
Cell Type
B cells, Macrophages, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Shibuya A, et al. 2000. Nat. Immunol. 1(5):441.
2. Sandor M, et al. 1992. J. Immunol.. 148(8):2363.
3. Cho Y, et al. 2010. Mol. Immunol. 47(4):878.

Gene ID
14125 View all products for this Gene ID 83953 View all products for this Gene ID
UniProt
View information about CD351 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 02.09.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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