- Clone
- 6B8/FMRP (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Fragile X mental retardation protein 1, POF, FMRP, POF1, FRAXA
- Previously
-
Covance Catalog# MMS-5231
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
834602 | 25 µL | 85€ | ||||
834601 | 100 µL | 220€ |
The gene encoding Fragile X mental retardation protein 1 (FMRP or FMR1), also known as premature ovarian failure 1 (POF1), contains multiple CGG sequence repeats that are positively correlated with impaired cognitive and reproductive function. FMRP may be involved in mRNA transport and synaptic protein synthesis. The gene that encodes FMRP is located in the X chromosome, and an abnormally large number of CGG repeats (200 - 1000 times) causes Fragile X syndrome due to inadequate amounts of FMRP, leading to severe learning deficiency and mental retardation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a recombinant protein isolated from baculovirus.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. For immunocytochemistry, a concentration range of 5.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody is effective in immunoblotting (WB) and immunocytochemistry (ICC).
The epitope for 6B8/FMRP lies between amino acids 345-350 of human FMRP. This clone does not cross react with FXR1 or FXR2 and is human specific.
This clone is also known as 6B8. -
Application References
(PubMed link indicates BioLegend citation) -
- LaFauci G, et al. 2013. J Mol Diagn. 15: 508-17
- Product Citations
-
- RRID
-
AB_2564992 (BioLegend Cat. No. 834602)
AB_2564992 (BioLegend Cat. No. 834601)
Antigen Details
- Structure
- Expected MW: 68-80 kD (smaller truncations of FMRP seen at lower molecular weights)
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology, Transcription Factors
- Molecular Family
- Postsynaptic proteins, Presynaptic proteins
- Gene ID
- 2332 View all products for this Gene ID
- UniProt
- View information about FMRP on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All FMRP Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-FMRP | 6B8/FMRP | WB,ICC |
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Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-FMRP
Western blot of purified anti-FMRP antibody (clone 6B8/FMRP)... ICC staining of purified anti-FMRP antibody (clone 6B8/FMRP)... ICC staining of purified anti-FMRP antibody (clone 6B8/FMRP)... Reactivity of 6B8/FMRP to cell lysates of lymphoblastoid cel... Western Blot showing human and murine specificity of FMRP (6...
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