Purified anti-mouse CD104 Antibody

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Clone: 346-11A (See other available formats)
Regulatory Status: RUO
Other Names: Integrin β4, β4 integrin, TSP-1180, ITGB4
Isotype: Rat IgG2a, κ
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Product Citations: publications

346-11A_Pure_042408 — Mouse lung carcinoma cell line (Line 1) stained with purified 346-11A, followed by anti-rat IgG-FITC.

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123602

500 µg

210€

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Description

CD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Tumor-associated antigen TSP-180 from BALB/c lung carcinoma
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
IHC - Reported in the literature, not verified in house
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported (for the relevant formats) applications include: immunohistochemical staining¹.
RRID: AB_961050 (BioLegend Cat. No. 123602)

Antigen Details

Structure: Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)
Distribution: Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset
Function: Adhesion
Ligand/Receptor: Laminins, keratin filaments
Cell Type: Embryonic Stem Cells, Endothelial cells, Epithelial cells, T cells
Biology Area: Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Kennel SJ, et al. 1992. J. Cell Sciences 101:1992.
Gene ID: 192897 View all products for this Gene ID
UniProt: View information about CD104 on UniProt.org

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Description	Clone	Applications

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Other Formats

View All CD104 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD104	346-11A	FC,IP,ELISA
Biotin anti-mouse CD104	346-11A	FC
FITC anti-mouse CD104	346-11A	FC
Alexa Fluor® 647 anti-mouse CD104	346-11A	FC
PE anti-mouse CD104	346-11A	FC
PerCP/Cyanine5.5 anti-mouse CD104	346-11A	FC
PE/Cyanine7 anti-mouse CD104	346-11A	FC
APC anti-mouse CD104	346-11A	FC
TotalSeq™-C1028 anti-mouse CD104	346-11A	PG
TotalSeq™-B1028 anti-mouse CD104	346-11A	PG

Certificate of Analysis

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Go To Top Version: 4 Revision Date: 06.20.2018

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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