Purified anti-human integrin β5 Antibody

Pricing & Availability
Clone
AST-3T (See other available formats)
Regulatory Status
RUO
Other Names
integrin b5, integrin beta 5, ITGB5
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
AST-3T_PE_110309
Human cervical cancer cell line HeLa stained with AST-3T PE.
  • AST-3T_PE_110309
    Human cervical cancer cell line HeLa stained with AST-3T PE.
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345202 100 µg 113€
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Description

Integrins are a family of transmembrane proteins. A total 17 integrin α chains and 8 β chains have been identified. The association of integrin α and β chains forms 25 integrin complexes which serve as extracellular matrix receptors and play important roles in cell adhesion and development. Integrin β5 is a 95 kD glycoprotein heterodimer with the αV subunit and is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. The αV/β5 integrin complex binds to vitronectin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Steinberg F, et al. 2012. J Cell Biol. 197:219. PubMed
  2. Fedr R, et al. 2023. Sci Rep. 13:4889. PubMed
  3. Zhang G, et al. 2019. FASEB J. 33:2823. PubMed
RRID
AB_2234046 (BioLegend Cat. No. 345202)

Antigen Details

Structure
Integrin family, Ig superfamily, associates with αV subunit
Distribution

Epithelial cells, endothelial cells, keratinocytes, osteoblastic cells

Function
Cell adhesion
Ligand/Receptor
vitronectin
Cell Type
Endothelial cells, Epithelial cells, Osteoclasts
Biology Area
Immunology
Molecular Family
Adhesion Molecules
Antigen References

1. Kim JP. et al. 1994. J. Bio. Chem. 269:26926
2. Cheng SL. et al. 2000. J. Cell Biochem. 77:265
3. Aplin JD. et al. 1996. Mol. Hum. Reprod. 2:527

Gene ID
3693 View all products for this Gene ID
UniProt
View information about Integrin beta 5 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 08.17.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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