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Purified anti-mouse CD103 Antibody

Pricing & Availability
Clone
W19396D (See other available formats)
Regulatory Status
RUO
Other Names
CD103, ITAGE, integrin alpha E
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
W19396D_PURE_CD103_Antibody_032822
C57BL/6 mouse splenocytes were stained with purified anti-mouse CD103 (clone W19396D) (left) or purified rat IgG2b, κ isotype control (right) followed by PE anti-rat IgG. Cells were costained with anti-mouse CD3 APC.
  • W19396D_PURE_CD103_Antibody_032822
    C57BL/6 mouse splenocytes were stained with purified anti-mouse CD103 (clone W19396D) (left) or purified rat IgG2b, κ isotype control (right) followed by PE anti-rat IgG. Cells were costained with anti-mouse CD3 APC.
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110902 100 µg 109€
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Description

CD103 is the alpha E integrin, which forms a heterodimer with integrin beta 7. The heterodimer complex binds to E-cadherin. It is expressed in on T cells, notably in subpopulations in the lamina propria, on regulatory T cells, or resident memory T cells, and a subset of dendritic cells in gut mucosa. CD103 is thought to be involved with homing to intestinal epithelial sites and has been associated with high levels of TGF-beta presence.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse integrin alphaE/beta7
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone W19396D can partially block binding of clone 2E7 on target cells.

RRID
AB_2922461 (BioLegend Cat. No. 110902)

Antigen Details

Structure
125 - 150 kD transmembrane glycoprotein, integrin
Distribution

Lamina propria T cells, regulatory T cells, resident memory T cells, subset of dendritic cells

Function
Adhesion, localization and activation of intestinal lymphocytes, lymphocyte homing
Interaction
Integrin β7
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Cell Adhesion, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Parker CM, et al. 1992. Proc Natl Acad Sci U S A. 89:1924-8.
  2. Kruschwitz M, et al. 1991. J Clin Pathol. 44:636-45.
  3. Schon MP, et al. 1999. J. Immunol. 162:6641-9.
  4. Shaw SK, et al. 1994. J Biol Chem. 269:6016-25.
Gene ID
3682 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org
Go To Top Version: 1    Revision Date: 03.28.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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