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Purified anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
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Product Citations
publications
HIT2_Purified_062507
Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC
  • HIT2_Purified_062507
    Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC
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303502 100 µg £42
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Horse, Cow
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Tornack J, et al. 2017. PLoS One. 12:e0169119. PubMed
  2. Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed
  3. Alpert A, et al. 2022. Cell Syst. 13:71. PubMed
  4. McCarthy EE, et al. 2022. Cell Rep. 39:110815. PubMed
  5. Feyaerts D, et al. 2022. Cell Rep Med. 3:100680. PubMed
  6. Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
  7. Meckiff BJ, et al. 2019. J Immunol. 203:1276. PubMed
  8. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  9. Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed
  10. Sullivan KD, et al. 2021. Cell Reports. 36(7):109527. PubMed
  11. Chakhtoura M, et al. 2021. PLoS Pathog. 17:e1009732. PubMed
  12. Roukens AHE, et al. 2022. Nat Immunol. 23:23. PubMed
  13. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  14. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  15. Vivanco Gonzalez N, et al. 2022. STAR Protoc. 3:101280. PubMed
  16. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  17. Syrimi E, et al. 2021. iScience. 24:103215. PubMed
  18. O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
  19. Olin A, et al. 2018. Cell. 174:1277. PubMed
  20. Galbraith MD, et al. 2021. eLife. 10:00. PubMed
  21. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  22. Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed
  23. Eccles JD, et al. 2020. Cell Rep. 30:351. PubMed
  24. Han L, et al. 2019. Haematologica. 10.3324/haematol.2018.205534. PubMed
  25. Gee MH, et al. 2018. Cell. 172:549. PubMed
  26. Newell KL, et al. 2021. PLoS One. 16:e0244855. PubMed
  27. Henrick BM, et al. 2021. Cell. . PubMed
  28. Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
  29. Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed
  30. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  31. NULL, et al. 2022. Cell. 185:916. PubMed
  32. Baum N, et al. 2020. Cancers (Basel). 13:. PubMed
  33. Zhou H, et al. 2017. Leukemia. 31:2065. PubMed
  34. Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
  35. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  36. Crawford LB, et al. 2021. J Virol. 95:. PubMed
  37. Chiou SH, et al. 2021. Immunity. 54:586. PubMed
  38. Li Z, et al. 2020. J Clin Lab Anal. 34:e23155. PubMed
RRID
AB_314354 (BioLegend Cat. No. 303502)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD38
Specificity Alt (DOES NOT SHOW ON TDS):
CD38
App Abbreviation (DOES NOT SHOW ON TDS):
FC,CyTOF®,IHC-F
UniProt
View information about CD38 on UniProt.org

Other Formats

View All CD38 Reagents Request Custom Conjugation
Description Clone Applications
APC anti-human CD38 HIT2 FC
FITC anti-human CD38 HIT2 FC
PE anti-human CD38 HIT2 FC
PE/Cyanine5 anti-human CD38 HIT2 FC
Purified anti-human CD38 HIT2 FC,CyTOF®,IHC-F
Alexa Fluor® 488 anti-human CD38 HIT2 FC
Alexa Fluor® 647 anti-human CD38 HIT2 FC
PE/Cyanine7 anti-human CD38 HIT2 FC
Biotin anti-human CD38 HIT2 FC
PerCP anti-human CD38 HIT2 FC
PerCP/Cyanine5.5 anti-human CD38 HIT2 FC
Alexa Fluor® 700 anti-human CD38 HIT2 FC,SB
Brilliant Violet 421™ anti-human CD38 HIT2 FC
Brilliant Violet 711™ anti-human CD38 HIT2 FC
Brilliant Violet 785™ anti-human CD38 HIT2 FC
Brilliant Violet 605™ anti-human CD38 HIT2 FC
APC/Cyanine7 anti-human CD38 HIT2 FC
Purified anti-human CD38 (Maxpar® Ready) HIT2 FC,CyTOF®
PE/Dazzle™ 594 anti-human CD38 HIT2 FC
PE anti-human CD38 HIT2 FC
Brilliant Violet 510™ anti-human CD38 HIT2 FC
FITC anti-human CD38 HIT2 FC
PE/Dazzle™ 594 anti-human CD38 HIT2 FC
TotalSeq™-A0389 anti-human CD38 HIT2 PG
TotalSeq™-C0389 anti-human CD38 HIT2 PG
APC/Fire™ 750 anti-human CD38 HIT2 FC
TotalSeq™-B0389 anti-human CD38 HIT2 PG
APC/Fire™ 810 anti-human CD38 HIT2 FC
Spark NIR™ 685 anti-human CD38 Antibody HIT2 FC
TotalSeq™-D0389 anti-human CD38 HIT2 PG
PerCP/Cyanine5.5 anti-human CD38 HIT2 FC
APC anti-human CD38 HIT2 FC
APC/Fire™ 750 anti-human CD38 HIT2 FC
PE/Cyanine7 anti-human CD38 HIT2 FC
GMP PE anti-human CD38 HIT2 FC
GMP FITC anti-human CD38 HIT2 FC
Pacific Blue™ anti-human CD38 HIT2 FC
Pacific Blue™ anti-human CD38 HIT2 FC
GMP APC/Fire™ 750 anti-human CD38 HIT2 FC
GMP PE/Dazzle™ 594 anti-human CD38 HIT2 FC
GMP APC anti-human CD38 HIT2 FC
GMP PE/Cyanine7 anti-human CD38 HIT2 FC
Spark Blue™ 515 anti-human CD38 HIT2 FC
GMP Pacific Blue™ anti-human CD38 HIT2 FC
Spark Violet™ 423 anti-human CD38 HIT2 FC
Brilliant Violet 650™ anti-human CD38 HIT2 FC
Spark PLUS B550™ anti-human CD38 HIT2 FC
Go To Top Version: 2    Revision Date: 12/16/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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