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APC anti-mouse IL-31 Antibody

Pricing & Availability
Clone
W17037B (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-31
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W17037B_APC_IL-31_Antibody_2_021122
PMA+ionomycin-stimulated (4 hours, in presence of brefeldin A) Th2-polarized BALB/c mouse CD4 T cells were stained with anti-mouse CD3 FITC. After fixation and permeabilization, cells were stained intracellularly with anti-mouse IL-31 (clone W17037B) APC (left) or rat IgG2a, κ isotype control (right).
  • W17037B_APC_IL-31_Antibody_2_021122
    PMA+ionomycin-stimulated (4 hours, in presence of brefeldin A) Th2-polarized BALB/c mouse CD4 T cells were stained with anti-mouse CD3 FITC. After fixation and permeabilization, cells were stained intracellularly with anti-mouse IL-31 (clone W17037B) APC (left) or rat IgG2a, κ isotype control (right).
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160705 25 µg £126
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160706 100 µg £233
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Description

IL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse IL-31
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC – Quality tested 
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2910331 (BioLegend Cat. No. 160705)
AB_2910331 (BioLegend Cat. No. 160706)

Antigen Details

Structure
Member of IL-6 family of cytokines
Distribution

Subset of CD4 T cells

Ligand/Receptor
IL-31Ra/OSMR
Cell Type
Lymphocytes, T cells, Th2, Thymocytes
Biology Area
Adaptive Immunity, Immunology, Innate Immunity
Molecular Family
Cytokines/Chemokines
Antigen References
  1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
  2. Arai I, et al. 2013. Exp. Dermatol. 22:669.
  3. Dai X, et al. 2013. PLoS One. 8:e67666.
  4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
  5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
  6. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5
Gene ID
76399 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
IL-31
Specificity Alt (DOES NOT SHOW ON TDS):
IL-31
App Abbreviation (DOES NOT SHOW ON TDS):
ICFC
UniProt
View information about IL-31 on UniProt.org
Go To Top Version: 1    Revision Date: 02/11/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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