- Clone
- GM26E7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Tryptase II, Granzyme-3, fragmentin-3, GZMK
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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370503 | 25 tests | £85 | ||||
370504 | 100 tests | £221 |
Granzyme K is a 29 kD serine protease found in cytoplasmic granules of cytotoxic lymphocytes and NK cells. Granzyme K is thought to induce cell death and lysis in response to non-self antigens on the cell surface by cleaving nucleosome assembly protein SET. Granzyme K is upregulated in several diseases associated with inflammation including arthritis, atherosclerosis, and asthma.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
-
Red Laser (633 nm)
- RRID
-
AB_2566674 (BioLegend Cat. No. 370503)
AB_2566674 (BioLegend Cat. No. 370504)
Antigen Details
- Structure
- Serine Protease, approximately 29 kD.
- Distribution
- Activated CD8+ cytotoxic T-cells, natural killer (NK) cells, and CD8+ T-cells.
- Function
- Cytotoxicity.
- Interaction
- SET
- Cell Type
- T cells, NK cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience
- Molecular Family
- Proteases, Enzymes and Regulators
- Antigen References
-
1. Vrazo AC, et al. 2015. Blood 126.
2. Cooper DM, et al. 2011. PLoS. One 6.
3. Wensink AC, et al. 2015. J. Immunol. 194:491.
4. Zhao T, et al. 2007. Cell Death Differ. 14:489. - Gene ID
- 3003 View all products for this Gene ID
- UniProt
- View information about Granzyme K on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Granzyme K Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human Granzyme K | GM26E7 | ICFC,ICC |
Alexa Fluor® 647 anti-human Granzyme K | GM26E7 | ICFC |
PerCP/Cyanine5.5 anti-human Granzyme K | GM26E7 | ICFC |
PE anti-human Granzyme K | GM26E7 | ICFC |
FITC anti-human Granzyme K | GM26E7 | ICFC |
APC anti-human Granzyme K | GM26E7 | ICFC |
PE/Cyanine7 anti-human Granzyme K | GM26E7 | ICFC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human Granzyme K
Human peripheral blood lymphocytes were fixed, permeabilized... -
Alexa Fluor® 647 anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 FIT... -
PerCP/Cyanine5.5 anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 FIT... -
PE anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 FIT... -
FITC anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 APC... -
APC anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 FIT... -
PE/Cyanine7 anti-human Granzyme K
Human peripheral blood lymphocytes were stained with CD8 FIT...
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