FITC anti-human Granzyme K Antibody anti-Granzyme K

Pricing & Availability

Clone: GM26E7 (See other available formats)
Regulatory Status: RUO
Other Names: Tryptase II, Granzyme-3, fragmentin-3, GZMK
Isotype: Mouse IgG1, κ
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Product Citations: publications

GM26E7_FITC_GranzymeK_Antibody_1_112916 — Human peripheral blood lymphocytes were stained with CD8 APC, fixed, permeabilized, and intracellularly stained with anti-human Granzyme K antibody (clone GM26E7) FITC (top) or mouse IgG1, κ FITC isotype control.

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370507

25 tests

£70

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370508

100 tests

£157

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Description

Granzyme K is a 29 kD serine protease found in cytoplasmic granules of cytotoxic lymphocytes and NK cells. Granzyme K is thought to induce cell death and lysis in response to non-self antigens on the cell surface by cleaving nucleosome assembly protein SET. Granzyme K is upregulated in several diseases associated with inflammation including arthritis, atherosclerosis, and asthma.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Blue Laser (488 nm)
RRID: AB_2632845 (BioLegend Cat. No. 370507)
AB_2632845 (BioLegend Cat. No. 370508)

Antigen Details

Structure: Serine Protease, approximately 29 kD.
Distribution: Activated CD8⁺ cytotoxic T-cells, natural killer (NK) cells, and CD8⁺ T-cells.
Function: Cytotoxicity.
Interaction: SET
Cell Type: T cells, NK cells
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience
Molecular Family: Proteases, Enzymes and Regulators
Antigen References: 1. Vrazo AC, et al. 2015. Blood 126.
2. Cooper DM, et al. 2011. PLoS. One 6.
3. Wensink AC, et al. 2015. J. Immunol. 194:491.
4. Zhao T, et al. 2007. Cell Death Differ. 14:489.
Gene ID: 3003 View all products for this Gene ID
UniProt: View information about Granzyme K on UniProt.org

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Other Formats

View All Granzyme K Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human Granzyme K	GM26E7	ICFC,ICC
Alexa Fluor® 647 anti-human Granzyme K	GM26E7	ICFC
PerCP/Cyanine5.5 anti-human Granzyme K	GM26E7	ICFC
PE anti-human Granzyme K	GM26E7	ICFC
FITC anti-human Granzyme K	GM26E7	ICFC
APC anti-human Granzyme K	GM26E7	ICFC
PE/Cyanine7 anti-human Granzyme K	GM26E7	ICFC

Certificate of Analysis

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Go To Top Version: 1 Revision Date: 11/29/2016

For Research Use Only. Not for diagnostic or therapeutic use.

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