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APC anti-human ROR2 Antibody

Pricing & Availability
Clone
W19338B (See other available formats)
Regulatory Status
RUO
Other Names
Tyrosine-protein kinase transmembrane receptor ROR2 , Neurotrophic tyrosine kinase, receptor-related 2,
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
W19338B_APC_ROR2_Antibody_071923
Human erythroleukemic cell line, K562, was stained with anti-human ROR2 (clone W19338B) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
  • W19338B_APC_ROR2_Antibody_071923
    Human erythroleukemic cell line, K562, was stained with anti-human ROR2 (clone W19338B) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
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378505 25 tests £118
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378506 100 tests £272
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Description

ROR2 is a receptor protein tyrosine kinase that belongs to the ROR subfamily of cell surface receptors. Both canonical and non-canonical Wnt proteins bind to the ROR2 receptor. ROR2 may play a role during embryonic development in the formation of chondrocytes and cartilage and growth plate development and mediates WNT5A-induced noncanonical Wnts signaling, which induces filopodia formation and cell migration.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Transfectant AA 1-472
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_3068221 (BioLegend Cat. No. 378505)
AB_3068221 (BioLegend Cat. No. 378506)

Antigen Details

Structure
Single-pass type I membrane protein
Distribution

Cell membrane

Function
ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, Wnt protein binding, transmembrane receptor protein tyrosine kinase activity
Interaction
Frizzled binding, mitogen-activated protein kinase kinase kinase binding
Ligand/Receptor
Wnt5a
Biology Area
Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability
Molecular Family
Protein Kinases/Phosphatase
Antigen References
  1. Masiakowski P, et al. 1992. J Biol Chem. 267:26181-90.
  2. O'Connell MP, et al. 2010. Oncogene. 29:34-44.
  3. Liu Y, et al. 2008. J Cell Biochem. 105:497-502.
  4. Schwarzer W, et al. 2009. Hum Mol Genet. 18:4013-21.

 

Gene ID
4920 View all products for this Gene ID
UniProt
View information about ROR2 on UniProt.org
Go To Top Version: 1    Revision Date: 07/19/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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