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APC anti-mouse CD200R (OX2R) Antibody

Pricing & Availability
Clone
OX-110 (See other available formats)
Regulatory Status
RUO
Other Names
OX-2R, Orexin Receptor 2 (OX2R), CD200R
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
OX-110_APC_CD200R_Antibody_062619.png
C57BL/6 mouse bone marrow cells were stained with CD200R (OX2R) (clone OX-110) APC (filled histogram) or Rat IgG2a, κ APC isotype control (open histogram). Data shown was gated on the myeloid cell population.
  • OX-110_APC_CD200R_Antibody_062619.png
    C57BL/6 mouse bone marrow cells were stained with CD200R (OX2R) (clone OX-110) APC (filled histogram) or Rat IgG2a, κ APC isotype control (open histogram). Data shown was gated on the myeloid cell population.
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123915 25 µg £90
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123916 100 µg £232
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Description

CD200R, also known as OX2R, is a membrane glycoprotein with up to 70% of its weight derived from N-linked glycosylation. CD200R is expressed primarily by monocytes and neutrophils but also by other leukocytes including T lymphocytes and mast cells. The interaction between CD200 and CD200R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue. Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function. Levels of expression on resting peripheral blood cells are relatively low.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Fusion protein mouse CD200RCD4d3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional applications (for the relevant formats) include: in vivo studies3. The Ultra-LEAF™ purified antibody is recommended for functional assays.

Application References

(PubMed link indicates BioLegend citation)
  1. Voulgaraki D, et al. 2005. Immunol. 115:337
  2. Stumper TL, et al. 2011. J. Immunol. 186:1970. PubMed
  3. Talebian F, et al. 2012. PLoS One 7:e31442. (FA)
Product Citations
  1. Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
  2. Geng S, et al. 2021. JCI Insight. 6:. PubMed
  3. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
RRID
AB_2810379 (BioLegend Cat. No. 123915)
AB_2810379 (BioLegend Cat. No. 123916)

Antigen Details

Distribution

Monocytes and neutrophils, T lymphocytes and mast cells

Cell Type
Mast cells, Monocytes, Neutrophils, T cells
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. Voulgaraki D, et al. 2005. Immunol. 115:337

Gene ID
57781 View all products for this Gene ID
UniProt
View information about CD200R on UniProt.org
Go To Top Version: 1    Revision Date: 06/26/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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