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PE anti-mouse CD200R (OX2R) Antibody

Pricing & Availability
Clone
OX-110 (See other available formats)
Regulatory Status
RUO
Other Names
OX-2R, Orexin Receptor 2 (OX2R), CD200R
Isotype
Rat IgG2a, κ
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Product Citations
publications
OX-110_PE_121508.jpg
C57BL/6 bone marrow cells stained with OX-110 PE (gated on myeloid population)
  • OX-110_PE_121508.jpg
    C57BL/6 bone marrow cells stained with OX-110 PE (gated on myeloid population)
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Cat # Size Price Quantity Check Availability Save
123907 25 µg £68
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123908 100 µg £150
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Description

CD200R, also known as OX2R, is a membrane glycoprotein with up to 70% of its weight derived from N-linked glycosylation. CD200R is expressed primarily by monocytes and neutrophils but also by other leukocytes including T lymphocytes and mast cells. The interaction between CD200 and CD200R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue. Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function. Levels of expression on resting peripheral blood cells are relatively low.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Fusion protein mouse CD200RCD4d3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional applications (for the relevant formats) include: in vivo studies3. The Ultra-LEAF™ purified antibody is recommended for functional assays.

Application References

(PubMed link indicates BioLegend citation)
  1. Voulgaraki D, et al. 2005. Immunol. 115:337
  2. Stumper TL, et al. 2011. J. Immunol. 186:1970. PubMed
  3. Talebian F, et al. 2012. PLoS One 7:e31442. (FA)
Product Citations
  1. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  2. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  3. Stubelius A, et al. 2017. Immunobiology. 10.1016/j.imbio.2017.05.007. PubMed
  4. Sumpter T, et al. 2011. J Immunol. 186:1970. PubMed
  5. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  6. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  7. Wang F, et al. 2021. Cell. 184(2):422-440.e17. PubMed
  8. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
  9. Casulli J, et al. 2019. Nat Commun. 10:2121. PubMed
  10. Najar M, et al. 2012. Immunol Lett. 146:50. PubMed
  11. Berrien–Elliott MM, et al. 2020. Immunity. 51(3):479-490. PubMed
  12. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  13. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
RRID
AB_2074080 (BioLegend Cat. No. 123907)
AB_2074080 (BioLegend Cat. No. 123908)

Antigen Details

Distribution

Monocytes and neutrophils, T lymphocytes and mast cells

Cell Type
Mast cells, Monocytes, Neutrophils, T cells
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. Voulgaraki D, et al. 2005. Immunol. 115:337

Gene ID
57781 View all products for this Gene ID
UniProt
View information about CD200R on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/01/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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