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APC anti-mouse CD270 (HVEM) Antibody

Pricing & Availability
Clone
HMHV-1B18 (See other available formats)
Regulatory Status
RUO
Other Names
Herpes virus entry mediator, TR2, tumor necrosis factor receptor like 2, TNFRSF14, HVEM
Isotype
Armenian Hamster IgG
Ave. Rating
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Product Citations
publications
HMHV-1B18_APC_021810
C57BL/6 splenocytes stained with HMHV-1B18 APC
  • HMHV-1B18_APC_021810
    C57BL/6 splenocytes stained with HMHV-1B18 APC
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136305 25 µg £94
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136306 100 µg £219
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Description

Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse HVEM-hIgG1Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
RRID
AB_2203829 (BioLegend Cat. No. 136305)
AB_2203829 (BioLegend Cat. No. 136306)

Antigen Details

Structure
A type I transmembrane protein of TNF-receptor superfamily.
Distribution

It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs.

Function
Play an important role in regulating lymphocyte activation and homeostasis in immune responses.
Ligand/Receptor
LIGHT, BTLA, LTα, CD160
Cell Type
B cells, Dendritic cells, Neutrophils
Biology Area
Cell Adhesion, Cell Biology, Immunology, Signal Transduction
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Fan Z, et al. 2006. Blood 107(4):1342
2. Granger SW, et al. 2008. Stem Cells. 27:653
3. Kwon BS, et al. 1997. J. Biol. Chem. 272:13471
4. Gonzalez LC, et al. 2005. Proc. Nat. Acad. Sci. U. S. A. 102:1116
5. Montgomery RI, et al. 1996. Cell. 87:427
6. Cheung TC, et al. 2009. Proc. Nat. Acad. Sci. U. S. A. 106 (15):6244
7. Cai G, et al. 2009. Immunol. Rev. 229(1):244

Gene ID
230979 View all products for this Gene ID
UniProt
View information about CD270 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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