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Brilliant Violet 421™ anti-human CD290 (TLR10) Antibody

Pricing & Availability
Clone
3C10C5 (See other available formats)
Regulatory Status
RUO
Other Names
Toll like receptor 10
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
3C10C5_BV421_CD290_Antibody_053024
Human peripheral blood lymphocytes were stained with anti-human CD19 (clone HIB19) APC and anti-human CD290 (TLR10) (clone 3C10C5) Brilliant Violet 421™ (left) or mouse IgG1, κ Brilliant Violet 421™ isotype control (right).
  • 3C10C5_BV421_CD290_Antibody_053024
    Human peripheral blood lymphocytes were stained with anti-human CD19 (clone HIB19) APC and anti-human CD290 (TLR10) (clone 3C10C5) Brilliant Violet 421™ (left) or mouse IgG1, κ Brilliant Violet 421™ isotype control (right).
See Brilliant Violet 421™ spectral data
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354607 25 tests £133
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354608 100 tests £279
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Description

CD290, also known as TLR10, is a 91-100 kD glycosylated protein belonging to the toll-like receptor family. It is expressed on B cell, Treg cells, and plasmacytoid dendritic cells but absent on T cells, particularly non-Treg and granulocytes. It can interact with MyD88 and plays an important role in innate immunity and pattern recognition.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified extracellular domain of human TLR10 (amino acids 20-474) (NP_001017388 )
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Guan Y, et al. 2010. J. Immunol. 184:5094.
RRID
AB_3662263 (BioLegend Cat. No. 354607)
AB_3662263 (BioLegend Cat. No. 354608)

Antigen Details

Structure
Member of the toll-like receptor family, type I membrane protein, 91-100 kD
Distribution

B cells, Treg cells, plasmacytoid DCs

Function
Interacts with MyD88 and TRAF6, which results in NF-kB activation and cytokine secretion
Ligand/Receptor
MyD88 and TRAF6
Cell Type
B cells, Dendritic cells, Tregs
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Toll Like Receptors
Antigen References

1. Chuang T, et al. 2001. Biochim. Biophys. Acta. 1518:157.
2. Hornung V, et al. 2002. J. Immunol. 168:4531.
3. Bourke E, et al. 2003. Blood 102:956.

Gene ID
81793 View all products for this Gene ID
UniProt
View information about CD290 on UniProt.org

Related FAQs

What is the F/P ratio range of our BV421™ format antibody reagents?

It is lot-specific. On average it ranges between 2-4.

Go To Top Version: 1    Revision Date: 05/30/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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