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PE anti-human CD290 (TLR10) Antibody

Pricing & Availability
Clone
3C10C5 (See other available formats)
Regulatory Status
RUO
Other Names
Toll like receptor 10
Isotype
Mouse IgG1, κ
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Product Citations
publications
3C10C5_PE_1_060812
Human peripheral blood lymphocytes were stained with CD19 APC and TLR10 (clone 3C10C5, top) PE or mouse IgG1, κ PE isotype control (bottom).
  • 3C10C5_PE_1_060812
    Human peripheral blood lymphocytes were stained with CD19 APC and TLR10 (clone 3C10C5, top) PE or mouse IgG1, κ PE isotype control (bottom).
  • 3C10C5_PE_2_060812
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354603 25 tests £105
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354604 100 tests £247
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Description

CD290, also known as TLR10, is a 91-100 kD glycosylated protein belonging to the toll-like receptor family. It is expressed on B cell, Treg cells, and plasmacytoid dendritic cells but absent on T cells, particularly non-Treg and granulocytes. It can interact with MyD88 and plays an important role in innate immunity and pattern recognition.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified extracellular domain of human TLR10 (amino acids 20-474) (NP_001017388 )
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Guan Y, et al. 2010. J. Immunol. 184:5094.
RRID
AB_11219598 (BioLegend Cat. No. 354603)
AB_11219598 (BioLegend Cat. No. 354604)

Antigen Details

Structure
Member of the toll-like receptor family, type I membrane protein, 91-100 kD
Distribution

B cells, Treg cells, plasmacytoid DCs

Function
Interacts with MyD88 and TRAF6, which results in NF-kB activation and cytokine secretion
Ligand/Receptor
MyD88 and TRAF6
Cell Type
B cells, Dendritic cells, Tregs
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Toll Like Receptors
Antigen References

1. Chuang T, et al. 2001. Biochim. Biophys. Acta. 1518:157.
2. Hornung V, et al. 2002. J. Immunol. 168:4531.
3. Bourke E, et al. 2003. Blood 102:956.

Gene ID
81793 View all products for this Gene ID
UniProt
View information about CD290 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08/18/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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