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- Clone
- QA20A86 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- gpIIb/gpIIIa
- Isotype
- Human IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood platelets were stained with anti-human CD41/CD61 recombinant (clone QA20A86) Brilliant Violet 605™ (filled histogram). Open histogram represents unstained cells.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 383105 | 25 tests | £152 | ||||
| 383106 | 100 tests | £298 | ||||
CD41/CD61, also known as gpIIb/IIIa, is a member of a family integrin receptors. This is a complex comprised by CD41 and CD61 through non-covalent association. CD41/CD61 is mainly expressed by platelets and megakaryocytes. The resting form of the CD41/CD61 complex is involved in platelet activation and aggregation by binding to immobilized fibrinogen. After activation, CD41/CD61 becomes a receptor for soluble fibrinogen and several other RGD-containing adhesive proteins such as von Willebrand Factor (vWF) and fibronectin. An absence or dysfunction of CD41/CD61 on the platelet surface results in an inherited bleeding disorder, called Glanzmann Thromsasthenia (GT). CD41/CD61 has been found on murine hematopoietic progenitor cells, indicating that this complex may play a role in regulating hematopoietic development.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Human
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 605™ excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- RRID
-
AB_3097491 (BioLegend Cat. No. 383105)
AB_3097491 (BioLegend Cat. No. 383106)
Antigen Details
- Structure
- Complex of CD41 and CD61 through non-covalent association
- Distribution
-
Platelets and megakaryocytes
- Function
- Mediates attachment to cells of diverse matrix proteins
- Ligand/Receptor
- Fibrinogen, RGD-containing adhesive proteins such as vonWillebrand Factor (vWF) and fibronectin
- Cell Type
- Megakaryocytes, Platelets
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Gene ID
- 3690 View all products for this Gene ID 3674 View all products for this Gene ID
- UniProt
- View information about CD41/CD61 on UniProt.org
Other Formats
View All CD41/CD61 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
| PE anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
| Brilliant Violet 605™ anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with purified ... -
PE anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with Brilliant... -
Brilliant Violet 605™ anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with anti-huma...
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