- Clone
- QA20A86 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- gpIIb/gpIIIa
- Isotype
- Human IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![QA20A86_PURE_CD41-CD61_Antibody_060722 QA20A86_PURE_CD41-CD61_Antibody_060722](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/QA20A86_PURE_CD41-CD61_Antibody_060722.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
-
Human peripheral blood platelets were stained with purified anti-human CD41/CD61 recombinant (clone QA20A86) (filled histogram) or purified human IgG1, κ isotype control (open histogram) and followed by PE anti-human IgG Fc.
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
383102 | 100 µg | £163 |
CD41/CD61, also known as gpIIb/IIIa, is a member of a family integrin receptors. This is a complex comprised by CD41 and CD61 through non-covalent association. CD41/CD61 is mainly expressed by platelets and megakaryocytes. The resting form of the CD41/CD61 complex is involved in platelet activation and aggregation by binding to immobilized fibrinogen. After activation, CD41/CD61 becomes a receptor for soluble fibrinogen and several other RGD-containing adhesive proteins such as von Willebrand Factor (vWF) and fibronectin. An absence or dysfunction of CD41/CD61 on the platelet surface results in an inherited bleeding disorder, called Glanzmann Thromsasthenia (GT). CD41/CD61 has been found on murine hematopoietic progenitor cells, indicating that this complex may play a role in regulating hematopoietic development.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Human
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2927828 (BioLegend Cat. No. 383102)
Antigen Details
- Structure
- Complex of CD41 and CD61 through non-covalent association
- Distribution
-
Platelets and megakaryocytes
- Function
- Mediates attachment to cells of diverse matrix proteins
- Ligand/Receptor
- Fibrinogen, RGD-containing adhesive proteins such as vonWillebrand Factor (vWF) and fibronectin
- Cell Type
- Megakaryocytes, Platelets
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Gene ID
- 3690 View all products for this Gene ID 3674 View all products for this Gene ID
- UniProt
- View information about CD41/CD61 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All CD41/CD61 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
PE anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
Brilliant Violet 605™ anti-human CD41/CD61 Recombinant Antibody | QA20A86 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with purified ... -
PE anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with Brilliant... -
Brilliant Violet 605™ anti-human CD41/CD61 Recombinant Antibody
Human peripheral blood platelets were stained with anti-huma...
Follow Us