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FITC anti-human CD104 Antibody

Pricing & Availability
Clone
58XB4 (See other available formats)
Regulatory Status
RUO
Other Names
Integrin β4, β4 integrin, TSP-1180, ITGB4
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
58XB4_FITC_021508
Human colon carcinoma cell line HT29 stained with 58XB4 FITC
  • 58XB4_FITC_021508
    Human colon carcinoma cell line HT29 stained with 58XB4 FITC
Compare all formats See FITC spectral data
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327805 25 tests £65
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327806 100 tests £150
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Description

CD104 is a 205 kD type I transmembrane glycoprotein, known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) forms α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Product Citations
  1. Pastar I, et al. 2021. J Clin Invest. :e133727. PubMed
RRID
AB_2129148 (BioLegend Cat. No. 327805)
AB_2129148 (BioLegend Cat. No. 327806)

Antigen Details

Structure
Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)
Distribution
Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset
Function
Adhesion
Ligand/Receptor
Laminins, keratin filaments
Cell Type
Epithelial cells, Endothelial cells, T cells, Embryonic Stem Cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kippenberger S, et al. 2004. J. Invest. Dermatol. 123:444.
2. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication

Gene ID
3691 View all products for this Gene ID
UniProt
View information about CD104 on UniProt.org
Go To Top Version: 2    Revision Date: 07/08/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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