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FITC anti-mouse CD107a (LAMP-1) Antibody

Pricing & Availability
Clone
1D4B (See other available formats)
Regulatory Status
RUO
Other Names
Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1
Isotype
Rat IgG2a, κ
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Product Citations
publications
1D4B_FITC_083107
Thioglycollate-elicited BALB/c mouse peritoneal macrophages stained with 1D4B FITC
  • 1D4B_FITC_083107
    Thioglycollate-elicited BALB/c mouse peritoneal macrophages stained with 1D4B FITC
Compare all formats See FITC spectral data
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121605 50 µg £65
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121606 200 µg £145
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Description

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
This monoclonal antibody was raised against NIH/3T3 mouse embryonic fibroblast tissue culture cell membranes. It has been mapped to the N-terminus of LAMP-1.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Product Citations
  1. Miyatake Y, et al. 2018. J Immunol. 201:3051. PubMed
  2. Villarreal D, et al. 2015. Vaccine. 33: 4313-4320. PubMed
  3. Gary EN, et al. 2022. Cell Rep Med. 3:100693. PubMed
  4. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  5. Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed
  6. Capellmann S, et al. 2023. Front Immunol. 14:1154416. PubMed
  7. Koh CH, et al. 2020. Cancer Immunol Res. 8:698. PubMed
  8. Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed
  9. Page N, et al. 2018. Immunity. 48:937. PubMed
  10. Konrath KM, et al. 2022. Cell Rep. 38:110318. PubMed
  11. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  12. Nagarajan D, et al. 2021. Immunol Cell Biol. 99:972. PubMed
  13. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  14. Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed
  15. Gary EN, et al. 2021. iScience. 24(7):102699. PubMed
  16. Goggi JL, et al. 2020. Mol Imaging Biol. 22:1392. PubMed
  17. Wang F, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:257. PubMed
  18. Zhou D, et al. 2022. Nat Commun. 13:5174. PubMed
  19. Wagle MV, et al. 2021. Nat Commun. 12:2782. PubMed
  20. Chen Z et al. 2019. Immunity. 51(5):840-855 . PubMed
  21. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  22. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  23. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  24. Yan Y, et al. 2018. JCI Insight. 3. PubMed
  25. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  26. Zhang Y, et al. 2018. Nat Commun. 9:6. PubMed
  27. Klein JC, et al. 2017. Nat Commun. 8:14600. PubMed
  28. Nembrini C, et al. 2011. Proc Natl Acad Sci U S A. 108:E989. PubMed
  29. He Y, et al. 2017. J Autoimmun. 10.1016/j.jaut.2017.04.001. PubMed
  30. Oliveira AC et al. 2017. eLife. 6 pii: e30883. PubMed
  31. Chen Z, et al. 2021. Cell. 184(5):1262-1280.e22. PubMed
  32. Reguzova A, et al. 2020. Vaccines (Basel). 8:. PubMed
  33. Bransi A, et al. 2015. Cancer Immunol Res. 3: 1279 - 1288. PubMed
  34. Tanegashima K et al. 2017. EBioMedicine. 24:247-256 . PubMed
  35. Wolf Y, et al. 2019. Cell. 179:219. PubMed
RRID
AB_572006 (BioLegend Cat. No. 121605)
AB_572006 (BioLegend Cat. No. 121606)

Antigen Details

Structure
LAMP-1 is a 406 amino acid protein with a molecular mass of 44 kD.
Gene ID
16783 View all products for this Gene ID
UniProt
View information about CD107a on UniProt.org
Go To Top Version: 2    Revision Date: 10/22/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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