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PE anti-human CD282 (TLR2) Antibody

Pricing & Availability
Clone
W15145C (See other available formats)
Regulatory Status
RUO
Other Names
TLR2
Isotype
Mouse IgG2a, κ
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Product Citations
publications
W15145C_PE_CD282_TLR2_Antibody_122017
Human peripheral blood monocytes were stained with PE anti-human CD282 (Clone W15145C) (filled histogram) or PE mouse IgG2a, κ isotype control (open histogram).
  • W15145C_PE_CD282_TLR2_Antibody_122017
    Human peripheral blood monocytes were stained with PE anti-human CD282 (Clone W15145C) (filled histogram) or PE mouse IgG2a, κ isotype control (open histogram).
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392305 25 tests £100
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392306 100 tests £230
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Description

Toll-like receptors are type I transmembrane signaling receptors which are critical for the innate host defense to pathogens. Toll-like receptor 2 (TLR2), known as CD282, has been identified as a receptor that is central to the innate immune system's response to lipoproteins of Gram-negative bacteria and Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length human TLR2 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
RRID
AB_2721628 (BioLegend Cat. No. 392305)
AB_2721628 (BioLegend Cat. No. 392306)

Antigen Details

Structure
IL-1R superfamily, TLR family, type 1 transmebrane protein, 90kD
Distribution

Monocytes, Granulocytes, endothelial and epithelial cells

Function
Activates innate host defense against bacterial pathogens
Ligand/Receptor
Microbial lipoproteins, peptidoglycans, lipoteichoic acid
Cell Type
Endothelial cells, Epithelial cells, Granulocytes, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Toll Like Receptors
Antigen References

1. Lien E, et al. 1999. J. Biol. Chem. 274:33419.
2. Lien E, et al. 2001. J. Biol. Chem. 276:1873.
3. Sabroe I, et al. 2002. J. Immunol. 168:4701.

Gene ID
7097 View all products for this Gene ID
UniProt
View information about CD282 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 12/21/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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