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PE anti-human TMPRSS2 Antibody

Pricing & Availability
Clone
S20014A (See other available formats)
Regulatory Status
RUO
Other Names
Transmembrane protease serine 2
Isotype
Mouse IgG1, κ
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Product Citations
publications
S20014A_PE_TMPRSS2_Antibody_031422
Human colorectal adenocarcinoma cell line, Caco-2, was stained with anti-human TMPRSS2 (clone S20014A) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • S20014A_PE_TMPRSS2_Antibody_031422
    Human colorectal adenocarcinoma cell line, Caco-2, was stained with anti-human TMPRSS2 (clone S20014A) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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378403 25 tests £126
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378404 100 tests £265
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Description

TMPRSS2 is a membrane-anchored protein that belongs to the serine protease family and is involved in many physiological and pathological processes. TMPRSS2 participates in proteolytic cascades and is important in normal physiological function of the prostate. Autocleavage leads to secretion of the protease domain. TMPRSS2 is involved in extracellular matrix disruption and metastasis of prostate cancer cells and activates several substrates, including pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14. TMPRSS2 promotes uptake of SARS-CoV-1, MERS-CoV, and SARS-CoV-2 viral particles of by proteolytic cleavage of ACE2 receptor and cleavage of coronavirus spike glycoproteins.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
huTMPRSS2 transfectant
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications include: Flow cytometry.

RRID
AB_2910438 (BioLegend Cat. No. 378403)
AB_2910438 (BioLegend Cat. No. 378404)

Antigen Details

Structure
Single-pass type II membrane protein
Distribution

Cell membrane, activated by cleavage and secreted

Function
Hydrolase, protease, serine protease
Interaction
ACE2, HGF, F2RL1, ST14
Cell Type
Epithelial cells, Platelets
Biology Area
Cancer Biomarkers, Cell Biology, COVID-19
Molecular Family
Proteases
Antigen References
  1. Hoffman M, et al. 2020. Cell. 181:271-280.
  2. Yu J, et al. 2010. Cancer Cell. 17:443-54.
  3. Shen LW, et al. 2017. Biochimie. 142:1-10.
Gene ID
7113 View all products for this Gene ID
UniProt
View information about TMPRSS2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 03/03/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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