- Clone
- 3G7A02 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![3G7A02_PeCy7_CD120b_Antibody_FC_101514 3G7A02_PeCy7_CD120b_Antibody_FC_101514](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/3G7A02_PeCy7_CD120b_Antibody_FC_101514.jpg&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood lymphocytes were stained with CD120b (clone 3G7A02) PE/Cyanine7 (filled histogram) or rat IgG2a, κ PE/Cyanine7 isotype control (open histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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358411 | 25 tests | £121 | ||||
358412 | 100 tests | £262 |
CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial CD120b recombinant protein expressed in 293E cells (22-211aa).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
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Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Product Citations
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- RRID
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AB_2564395 (BioLegend Cat. No. 358411)
AB_2564396 (BioLegend Cat. No. 358412)
Antigen Details
- Structure
- 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI
- Distribution
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Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes
- Function
- When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 that possess ubiquitin ligase activity; cysteine rich extracellular region
- Interaction
- Interacts with TTRAP and TRAF2
- Ligand/Receptor
- TNF-α and TNF-β (LT-α)
- Cell Type
- Granulocytes, Lymphocytes, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors
- Molecular Family
- CD Molecules
- Antigen References
-
1. Andrews JS, et al. 1990. J. Immunol. 144:2582.
2. Nophar Y, et al. 1990. EMBO J. 9:3269.
3. Kohno T, et al. 1990. Proc. Natl. Acad. Sci. USA 87:8331.
4. Tartaglia LA, et al. 1991. Proc. Natl. Acad. Sci. USA 88:9292.
5. Hijdra D, et al. 2012. J. Inflamm. (Lond). 9:38.
6. Chen X, et al. 2013. J. Immunol. 190:1076. - Gene ID
- 7133 View all products for this Gene ID
- UniProt
- View information about CD120b on UniProt.org
Other Formats
View All CD120b Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD120b | 3G7A02 | FC |
PE anti-human CD120b | 3G7A02 | FC |
APC anti-human CD120b | 3G7A02 | FC |
Ultra-LEAF™ Purified anti-human CD120b | 3G7A02 | Neut,FC |
Biotin anti-human CD120b | 3G7A02 | FC |
PE/Cyanine7 anti-human CD120b | 3G7A02 | FC |
PE/Dazzle™ 594 anti-human CD120b | 3G7A02 | FC |
TotalSeq™-A1024 anti-human CD120b | 3G7A02 | PG |
TotalSeq™-C1024 anti-human CD120b | 3G7A02 | PG |
TotalSeq™-D1024 anti-human CD120b Antibody | 3G7A02 | PG |
TotalSeq™-B1024 anti-human CD120b | 3G7A02 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD120b
Human peripheral blood lymphocytes were stained with purifie... -
PE anti-human CD120b
Human peripheral blood lymphocytes were stained with human C... -
APC anti-human CD120b
Human peripheral blood lymphocytes were stained with human C... -
Ultra-LEAF™ Purified anti-human CD120b
TNF-RII/TNFRSF1B inhibition of TNF-α-induced cytotoxic... -
Biotin anti-human CD120b
Human peripheral blood lymphocytes were stained with biotiny... -
PE/Cyanine7 anti-human CD120b
Human peripheral blood lymphocytes were stained with CD120b ... -
PE/Dazzle™ 594 anti-human CD120b
Human peripheral blood lymphocytes were stained with human C... -
TotalSeq™-A1024 anti-human CD120b
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TotalSeq™-C1024 anti-human CD120b
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TotalSeq™-D1024 anti-human CD120b Antibody
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TotalSeq™-B1024 anti-human CD120b
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