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Purified anti-Calretinin Antibody

Pricing & Availability
Clone
A18241B (See other available formats)
Regulatory Status
RUO
Other Names
CR, 29 KDa calbindin, CAB29, CALB2, Calbindin 2, Calbindin D29K, CAL2
Isotype
Mouse IgG2b, κ
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Product Citations
publications
A18241B_PURE_Calretinin_Antibody_1_031120
Western blot of purified anti-Calretinin antibody (clone A18241B). Lane 1: Molecular weight marker; Lane 2: 20 µg of human cerebellum lysate; Lane 3: 20 µg of mouse cerebellum lysate; Lane 4: 20 µg of rat cerebellum lysate. The blot was incubated with 0.1 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • A18241B_PURE_Calretinin_Antibody_1_031120
    Western blot of purified anti-Calretinin antibody (clone A18241B). Lane 1: Molecular weight marker; Lane 2: 20 µg of human cerebellum lysate; Lane 3: 20 µg of mouse cerebellum lysate; Lane 4: 20 µg of rat cerebellum lysate. The blot was incubated with 0.1 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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871401 25 µg £73
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871402 100 µg £189
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Description

Calretinin is a calcium-binding protein that is abundantly expressed in interneurons and multiple regions of the brain, including the brainstem, hypothalamus, hippocampus, and cerebellum. Calretinin is involved in regulating intracellular calcium signaling and modulating neuronal excitability. Loss and reorganization of calretinin-positive interneurons have been indicated as possible cause in human epilepsy. In addition, calretinin is considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human CALB2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 2.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2861109 (BioLegend Cat. No. 871401)
AB_2861109 (BioLegend Cat. No. 871402)

Antigen Details

Structure
Human calretinin is a 271 amino acid protein with a predicted molecular mass of 31 kD.
Distribution

Tissue distribution: Brain
Cellular distribution: Cytosol, cytoskeleton, nucleus, plasma membrane

Function
Calretinin regulates intracellular calcium signaling and modulates neuronal excitability.
Cell Type
Neurons
Biology Area
Cell Biology, Neuroinflammation, Neuroscience, Synaptic Biology
Antigen References
  1. Wörthmüller J, et al. 2018. Oncotarget. 9(91):36256-36272.
  2. Christel CJ, et al. 2012. J Biol Chem. 287(47):39766-75.
  3. Tóth K, et al. 2010. Brain. 133(9):2763-77.
Gene ID
794 View all products for this Gene ID
UniProt
View information about Calretinin on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/11/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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