Purified anti-human CD49a Antibody anti-CD49a

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Clone: TS2/7 (See other available formats)
Regulatory Status: RUO
Other Names: α1 integrin, VLA-1 α chain, Integrin α1 chain, ITGA1
Isotype: Mouse IgG1, κ
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Product Citations: publications

Human cervical cancer cell line, Hela, stained with purified TS2/7, followed by anti-mouse IgG FITC

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328302

100 µg

£77

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Description

CD49a is a 200 kD type I transmembrane glycoprotein also known as α₁ integrin, VLA-1 α chain, or Integrin α₁. It associates with CD29 (β₁ integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. It is expressed on activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus, Rhesus
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human CTL line
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications include: immunoprecipitation¹, immunohistochemical staining¹ of acetone-fixed frozen tissue sections, and spatial biology (IBEX)^3,4.
RRID: AB_1236385 (BioLegend Cat. No. 328302)

Antigen Details

Structure: Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. Associates with CD29 to form VLA-1 complex
Distribution: Activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells
Function: Adhesion, leukocyte migration
Ligand/Receptor: With integrin β₁ (CD29) forms receptor for laminin-1 and collagen IV
Cell Type: Fibroblasts, Mesenchymal cells, Mesenchymal Stem Cells, Monocytes, NK cells, T cells
Biology Area: Immunology, Stem Cells
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss Press. p122

Boiret N, et al. 2005. Exp. Hematol. 33:219
Gene ID: 3672 View all products for this Gene ID
UniProt: View information about CD49a on UniProt.org

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Other Formats

View All CD49a Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD49a	TS2/7	FC
FITC anti-human CD49a	TS2/7	FC
PE anti-human CD49a	TS2/7	FC,SB
Alexa Fluor® 647 anti-human CD49a	TS2/7	FC,SB
PE/Cyanine7 anti-human CD49a	TS2/7	FC
APC anti-human CD49a	TS2/7	FC
TotalSeq™-A0575 anti-human CD49a	TS2/7	PG
APC/Fire™ 750 anti-human CD49a	TS2/7	FC
TotalSeq™-C0575 anti-human CD49a	TS2/7	PG
PerCP/Cyanine5.5 anti-human CD49a	TS2/7	FC
TotalSeq™-B0575 anti-human CD49a Antibody	TS2/7	PG

Certificate of Analysis

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Go To Top Version: 2 Revision Date: 08/31/2022

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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