- Clone
- Poly19051 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Loricrin
- Isotype
- Rabbit Polyclonal
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
905103 | 25 µg | £86 | ||||
905104 | 100 µg | £240 |
Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Polyclonal
- Host Species
- Rabbit
- Immunogen
- This antibody was raised against a peptide sequence derived from the C-terminus of the mouse loricrin protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemisty, a concentration range of 1.0 - 10 μg/mL is suggested. For Western blotting, a usage of 1.0 μg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product may contain other non-IgG subtypes.
-
Application References
(PubMed link indicates BioLegend citation) -
- Suzuki K, et al. 2009. Development 136:367. (IHC-P) PubMed
- Product Citations
-
- RRID
-
AB_2734676 (BioLegend Cat. No. 905103)
AB_2734676 (BioLegend Cat. No. 905104)
Antigen Details
- Structure
- Loricrin is a 312 amino acid protein with a molecular mass of 26 kD. Observed MW for human may also be 35 kD.
- Distribution
-
Tissue distribution: skin.
Cellular distribution: nucleus and plasma membrane. - Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Antigen References
-
1. Wallace L. 2012. J. Cell Sci. 125:1750. (IHC, WB) PubMed
2. Bayo P, et al. 2008. Endocrinology 149:1377. (IHC) PubMed
3. Hu Y, et al. 2001. Nature 410:710. PubMed
4. Croyle MJ, et al. 2011. Development 138:1675. (IF) PubMed
5. Sengupta A, et al. 2010. PLoS One 5(8):e12249. (IHC) PubMed
6. Liakath-Ali K, et al. 2014. Nat. Commun. 5:3540. (IF) PubMed - Gene ID
- 4014 View all products for this Gene ID
- UniProt
- View information about Loricrin on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Loricrin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Loricrin | Poly19051 | IHC-P,WB |
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