- Clone
- 8G10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
- Previously
-
Covance Catalog# MMS-5301
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
844402 | 25 µL | £73 | ||||
844401 | 100 µL | £189 |
Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Antibody is against amino acids 100 - 500 of human LRRK2.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2565614 (BioLegend Cat. No. 844402)
AB_2565614 (BioLegend Cat. No. 844401)
Antigen Details
- Structure
-
This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.
Expected MW: >200 kD - Distribution
-
Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome - Function
- LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.
- Biology Area
- Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Mitochondrial Markers
- Antigen References
-
- Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600.
- Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34.
- Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511–25.
- Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394–406.
- Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474–84.
- Gene ID
- 120892 View all products for this Gene ID
- UniProt
- View information about LRRK2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All LRRK2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-LRRK2 | 8G10 | WB |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-LRRK2
Western blot of purified anti-LRRK2 antibody (clone 8G10). L...
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