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Purified anti-mouse CD268 (BAFF-R) Antibody

Pricing & Availability
Clone
7H22-E16 (See other available formats)
Regulatory Status
RUO
Other Names
BR3, BAFFR, BAFF receptor, TNFRSF13C, B cell-activating factor receptor, BLys receptor 3
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
A_7H22-E16_PE_060309.jpg
C57BL/6 mouse splenocytes stained with purified 7H22-E16 conjugated to PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC
  • A_7H22-E16_PE_060309.jpg
    C57BL/6 mouse splenocytes stained with purified 7H22-E16 conjugated to PE (upper) or rat IgG1 PE isotype control (lower panel) and CD45R/B220 APC
  • B_7H22-E16_PE_060309.jpg
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134102 500 µg £201
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Description

BAFF (B cell-activating factor belonging to the TNF family) receptor (BAFF-R) is one of the three receptors that bind to BAFF. It is a type III transmembrane TNF receptor family member. BAFF-R is expressed at high levels in resting B cells and at lower levels in activated B cells, a small subset of activated/memory CD4+ T cells. It is a major mediator of BAFF dependent co-stimulatory response in peripheral B and T cells. It was reported that the mice expressing defective BAFF-R have disrupted B cell maturation. BAFF receptor appears to be particularly important for the regulation of normal B cell survival and maturation, as well as in the pathophysiology of aggressive B-cell malignancies and autoimmune diseases.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse BAFF receptor transfected rat RBL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al. 2006. Eur. J. Immunol. 36:1837.
  2. Ng LG, et al. 2004. J Immunol. 173:807.
  3. Batten M, et al. 2000. J. Exp. Med. 192:1453.
  4. Fu L, et al. 2009. Blood 113:4627.
Product Citations
  1. Lee-Chang C, et al. 2021. J Exp Med. 218:. PubMed
RRID
AB_1626123 (BioLegend Cat. No. 134102)

Antigen Details

Structure
A type III transmembrane TNF receptor family member
Distribution

Expressed on most B cells, a small subset of CD4+ T cells.

Function
Play an importance role in B cell development, maturation, and survival.
Ligand/Receptor
BAFF (BLyS)
Cell Type
B cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Thompson JS, et al. 2001. Science 293:2108.
2. Schiemann B, et al. 2001. Science 293:2111.
3. Batten M, et al. 2000. J. Exp. Med. 192:1453.
4. Fu L, et al. 2009. Blood 113:4627.

Gene ID
72049 View all products for this Gene ID
UniProt
View information about CD268 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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