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- Clone
- QA19A45 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse bone marrow myeloid cells were stained with anti-mouse Ly-6G/Ly-6C (Gr-1) FITC and purified anti-mouse/human CD11b recombinant (clone QA19A45) (left), or rat IgG2a, κ isotype control (right), followed by anti-rat IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 163702 | 100 µg | £37 | ||||
CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.
Product DetailsProduct Details
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Recombinant
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2892339 (BioLegend Cat. No. 163702)
Antigen Details
- Structure
- Integrin family, associates with integrin β2 (CD18), 170 kD
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells.
- Function
- Adhesion, chemotaxis
- Ligand/Receptor
- ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
- Antigen References
-
1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653. - Gene ID
- 16409 View all products for this Gene ID 3684 View all products for this Gene ID
- UniProt
- View information about CD11b on UniProt.org
Other Formats
View All CD11b Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse/human CD11b Recombinant Antibody | QA19A45 | FC |
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Purified anti-mouse/human CD11b Recombinant Antibody
C57BL/6 mouse bone marrow myeloid cells were stained with an...
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