Purified anti-human CD159a (NKG2A), CD159a, S19004C

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Clone: S19004C (See other available formats)
Regulatory Status: RUO
Other Names: Killer Cell Lectin Like Receptor C1, KLRC1, NK Cell Receptor A
Isotype: Mouse IgG1, κ
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Product Citations: publications

S19004C_PURE_CD159a_Antibody_1_041620 — Human peripheral blood lymphocytes were stained with purified CD159a (NKG2A) (clone S19004C) (left) or purified mouse IgG1, κ isotype ctrl (right), followed by anti-mouse IgG PE and CD3 Pacific Blue™.

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375102

100 µg

£241

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Description

CD159a, also known as NKG2A or KLRC1, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2A is an inhibitory NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2A/CD94 complex interacts HLA-E on target cells and inhibits T cells and NK cell effector functions. Recent studies showed that NKG2A blockade enhances the anti-tumor effect of NK cell and CD8⁺ T cells.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human NKG2A/CD94-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone S19004C does not cross-react with mouse CD159a.
RRID: AB_2888860 (BioLegend Cat. No. 375102)

Antigen Details

Structure: Type II transmembrane proteins of the C-type lectin superfamily
Distribution: NK cells, NKT cells, T cell subsets
Function: Inhibiting NK cell receptor
Ligand/Receptor: HLA-E
Cell Type: Lymphocytes, NK cells, NKT cells, T cells
Biology Area: Immuno-Oncology, Immunology
Molecular Family: Immune Checkpoint Receptors
Antigen References: Brooks AG, et al. 1999. J Immunol. 162:305-13.

Kaiser BK, et al. 2008. Proc Natl Acad Sci U S A. 105: 6696-701.

Braud VM, et al. 2003. Trends Immunol. 24:162-4.

Kamiya T, et al. 2019. J Clin Invest. 129:2094.

André P, et al. 2018. Cell. 175:1731.
Gene ID: 3821 View all products for this Gene ID
UniProt: View information about CD159a on UniProt.org

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Other Formats

View All CD159a Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD159a (NKG2A)	S19004C	FC
PE anti-human CD159a (NKG2A)	S19004C	FC
APC anti-human CD159a (NKG2A) Antibody	S19004C	FC
Pacific Blue™ anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Cyanine7 anti-human CD159a (NKG2A) Antibody	S19004C	FC
Alexa Fluor® 647 anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Cyanine5 anti-human CD159a (NKG2A)	S19004C	FC
APC/Fire™ 750 anti-human CD159a (NKG2A)	S19004C	FC
Alexa Fluor® 700 anti-human CD159a (NKG2A) Antibody	S19004C	FC
PE/Dazzle™ 594 anti-human CD159a (NKG2A) Antibody	S19004C	FC
Biotin anti-human CD159a (NKG2A) Antibody	S19004C	FC
Alexa Fluor® 488 anti-human CD159a (NKG2A)	S19004C	FC
PerCP/Cyanine5.5 anti-human CD159a (NKG2A)	S19004C	FC
FITC anti-human CD159a (NKG2A)	S19004C	FC
TotalSeq™-C1374 anti-human CD159a (NKG2A)	S19004C	PG
TotalSeq™-D1374 anti-human CD159a (NKG2A)	S19004C	PG
TotalSeq™-A1374 anti-human CD159a (NKG2A)	S19004C	PG
APC/Fire™ 810 anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 421™ anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 605™ anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 785™ anti-human CD159a (NKG2A)	S19004C	FC
TotalSeq™-B1374 anti-human CD159a (NKG2A)	S19004C	PG
PerCP/Fire™ 806 anti-human CD159a (NKG2A)	S19004C	FC
PerCP/Fire™ 780 anti-human CD159a (NKG2A)	S19004C	FC
PE/Fire™ 810 anti-human CD159a (NKG2A)	S19004C	FC
APC/Cyanine7 anti-human CD159a (NKG2A)	S19004C	FC
Brilliant Violet 650™ anti-human CD159a (NKG2A)	S19004C	FC
Spark Red™ 718 anti-human CD159a (NKG2A) (Flexi-Fluor™)	S19004C	FC
Brilliant Violet 711™ anti-human CD159a (NKG2A)	S19004C	FC

Certificate of Analysis

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Go To Top Version: 1 Revision Date: 04/16/2020

For Research Use Only. Not for diagnostic or therapeutic use.

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