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| Plasmacytoid dendritic cells (pDC) can be found in the small intestine and fight viruses by releasing copious amounts of type I interferons and IL-12. However, the gut serves as an entry point for several viruses, which can manipulate the host to increase ATP production, simultaneously promoting their own growth while lowering pDC numbers. CD203c (E-NPP3) is highly expressed on intestinal epithelial cells and regulates luminal ATP concentrations by cleaving ATP. In an article by Furuta et al., CD203-/- mice had higher ATP in the gut lumen and decreased numbers of pDCs. These cells tend to be highly sensitive to ATP-induced death via the P2X7 receptor as measured by Annexin V binding and activated Caspase 3. BioLegend provides reagents for each of these apoptosis factors and additional chemical probes to help assess cell health. |
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| Adapted from Furuta Y. et al. 2017. PLoS One. 12:e0172509. Pubmed |
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