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PE anti-human MRGX2 Antibody

Pricing & Availability
Clone
K125H4 (See other available formats)
Regulatory Status
RUO
Other Names
Mas-related G-protein coupled receptor member X2, MRGPRX2
Isotype
Mouse IgG2b, κ
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Product Citations
publications
K125H4_PE_MRGX2_Antibody_FC_070313
Human MRGX2 transfected CHO cells were stained with MRGX2 (clone K125H4) PE (filled histogram) or mouse IgG2b, κ PE isotype control (open histogram).
  • K125H4_PE_MRGX2_Antibody_FC_070313
    Human MRGX2 transfected CHO cells were stained with MRGX2 (clone K125H4) PE (filled histogram) or mouse IgG2b, κ PE isotype control (open histogram).
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359003 25 tests $165
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359004 100 tests $396
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Description

MRGX2 (Mas-related G-protein coupled receptor member X2) is a 36 kD, seven transmembrane protein expressed on mast cells and sensory neurons from the dorsal root ganglia. MRGX2 is involved in mast cell-degranulation, and may regulate the function and development of sensory neurons. Originally described as an orphan receptor, it has been reported MRGX2 binds defensins and costistatin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
DNA vaccine containing the full length gene of human MRGX2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Bawazir M, et al. 2022. Front Immunol. 13:1033794. PubMed
  2. Elst J, et al. 2021. J Immunol Methods. 495:113061. PubMed
  3. Leveque E, et al. 2022. Cancers (Basel). 14:. PubMed
  4. Elst J, et al. 2022. Front Immunol. 13:835618. PubMed
  5. Gupta K, et al. 2017. Infect Immun. 10.1128/IAI.00246-17. PubMed
  6. Chompunud Na Ayudhya C, et al. 2021. Int J Mol Sci. 22: . PubMed
  7. Plum T, et al. 2020. Immunity. 52(2):404-416. PubMed
RRID
AB_2562300 (BioLegend Cat. No. 359003)
AB_2562300 (BioLegend Cat. No. 359004)

Antigen Details

Structure
Seven transmembrane domains, 36 kD, member of the GPCR family
Distribution

Mast cells, sensory neurons from the dorsal root ganglia

Function
Involved in mast cell-degranulation, may regulate function and development of sensory neurons
Interaction
Coupled to G-proteins Gαq and Gαi
Ligand/Receptor
Defensins, cortistatin
Cell Type
Mast cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Subramanian H, et al. 2013. J. Immunol. 191:345.
2. Subramanian H, et al. 2011. J. Biol. Chem. 286:44739. 
3. Yang S, et al. 2005. Gene. 352:30.
4. Robas N, et al. 2003. J. Biol. Chem. 278:44400.

Gene ID
117194 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
MRGX2
Specificity Alt (DOES NOT SHOW ON TDS):
MRGX2
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about MRGX2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 07/16/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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