- Clone
- 3E3F9 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- C-Type Lectin Domain Family 4 Member F (CLEC4F), C-Type Lectin, Superfamily Member 13 (CLECSF13), Kupffer cell receptor (KCR), KCLR
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
156803 | 25 µg | $147 | ||||
156804 | 100 µg | $364 |
CLEC4F, also known as Kupffer cell receptor or KCR, is an 80 kDa type II transmembrane glycoprotein of the C-type lectin superfamily. It is expressed on resident Kupffer cells and infiltrating monocytes in the liver but not on macrophages in other tissues. CLEC4F interacts with alpha-galactosylceramide (α-GalCer) in a calcium-dependent manner and participates in the presentation of α-GalCer to natural killer T (NKT) cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-F - Quality tested
3D IHC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 2.5 - 10 µg/mL is suggested. For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
-
Red Laser (633 nm)
- Product Citations
-
- RRID
-
AB_2814081 (BioLegend Cat. No. 156803)
AB_2814081 (BioLegend Cat. No. 156804)
Antigen Details
- Structure
- Type II transmembrane glycoprotein
- Distribution
-
Kupffer cells
- Function
- Modulates glycolipids presentation on Kupffer cells.
- Ligand/Receptor
- Fucose, Galactose, N-acetylgalactosamine, un-sialylated glucosphingolipids with GalNAc or Gal terminus
- Antigen References
-
- Yang CY, et al. 2013. PLoS One. 8(6):e65070.
- van der Tuin SJL, et al. 2018. J Am Heart Assoc. 7(6)
- Hsieh SL, et al. 2009. J. Immunol. 182:78.38.
- Gene ID
- 51811 View all products for this Gene ID
- UniProt
- View information about CLEC4F on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All CLEC4F Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Alexa Fluor® 647 anti-mouse CLEC4F | 3E3F9 | IHC-F,3D IHC |
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Alexa Fluor® 647 anti-mouse CLEC4F
C57BL/6 mouse frozen liver section was fixed with 4% parafor... Paraformaldehyde-fixed (1%), 500 μm-thick mouse liver tissue...
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