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Anti-CD271 (p75NTR) Antibody (Previously Covance catalog# PRB-602C)

Pricing & Availability
Clone
Poly18397 (See other available formats)
Regulatory Status
RUO
Other Names
Tumor Necrosis Factor Receptor Superfamily Member 16, P75 Icd, Ngf Receptor, Tnfr Superfamily, Member 16, Low Affinity Neurotrophin Receptor P75Ntr
Previously
Covance Catalog# PRB-602C
Isotype
Rabbit Polyclonal IgG
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Product Citations
publications
Poly18397_Serum_CD271_Antibody_031521
IHC staining of purified anti-CD271 (p75NTR) antibody (Poly18397) on formalin-fixed, paraffin-embedded human tonsil. The tissue was incubated with primary antibody (1:500 dilution) for 60 minutes at room temperature. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929501) was used for detection followed by hemotoxylin counterstaining, according to the protocol provided.
  • Poly18397_Serum_CD271_Antibody_031521
    IHC staining of purified anti-CD271 (p75NTR) antibody (Poly18397) on formalin-fixed, paraffin-embedded human tonsil. The tissue was incubated with primary antibody (1:500 dilution) for 60 minutes at room temperature. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929501) was used for detection followed by hemotoxylin counterstaining, according to the protocol provided.
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839701 200 µL $356
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Description

p75 plays a pivotal role in the regulation of life and death decisions within developing neurons.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Polyclonal
Host Species
Rabbit
Immunogen
This polyclonal antibody was raised against residues 274-425 of rat p75NTR. This sequence comprises the C-terminal intracellular domain.
Preparation
Serum
Storage & Handling
Store at -20°C. It is suggested that the total volume be divided into useable aliquots upon initial thaw.
Application

IHC-P - Quality tested
ICC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a dilution of 1:500 is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is effective in immunoblotting, immunohistochemistry, immunoprecipitation and immunofluorescence.

*Predicted MW = 75 kD


This product may contain other non-IgG subtypes.

Application References

(PubMed link indicates BioLegend citation)
  1. Kim JY, et al. 2003. J Neurosci. 23:5561-71. (IHC)
  2. Bhakar AL, et al. 1999. J Biol Chem. 274:21443-9.
  3. Roux PP, et al. 1999. J Neurosci. 19:6887-96.
  4. Majdan M, et al. 1997. J Neurosci. 17:6988-98.
  5. Shen W, et al. 2014. PLoS One.9:104759. (WB) PubMed
  6. Butowt R, et al. 2009. J Neurosci. 34:10715. (IP) PubMed
  7. Fukumoto S, et al. 2004. J Cell Sci. 167:973. (IHC) PubMed
  8. Jaaro H, et al. 2005. Mol Cell Proteomics. 4:328. (IF) PubMed
  9. Wang S. et al. 2020. Macromolecular Rapid Comm. 41:e2000295. (ICC)
Product Citations
  1. Chen M, et al. 2020. Sci Rep. 1.077083333. PubMed
  2. Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed
  3. Bartheld R 2009. J Neurosci. 29:10715-10729. PubMed
  4. Jaaro H, Fainzilber Z 2005. Mol Cell Proteomics. 4:328-333. PubMed
  5. Delbary-Gossart S, et al. 2016. Brain. 139: 1762 - 1782. PubMed
  6. Tosolini AP, et al. 2022. Acta Neuropathol Commun. 10:121. PubMed
  7. Shen W, et al. 2014. PLoS One. 9:e104759. PubMed
  8. Fukumoto S, et al. 2004. J Cell Biol. 167:973-983. PubMed
  9. Budzinska MI, et al. 2020. J Cell Sci. 133:jcs242412. PubMed
RRID
AB_2565441 (BioLegend Cat. No. 839701)

Antigen Details

Cell Type
Mesenchymal Stem Cells
Biology Area
Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Postsynaptic proteins
Gene ID
4804 View all products for this Gene ID
UniProt
View information about CD271 on UniProt.org
Go To Top Version: 4    Revision Date: 04/27/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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