- Clone
- S16018A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD288, Toll-like receptor 8
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
395505 | 25 tests | $172 | ||||
395506 | 100 tests | $350 |
Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TLR8-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- RRID
-
AB_2801050 (BioLegend Cat. No. 395505)
AB_2801050 (BioLegend Cat. No. 395506)
Antigen Details
- Structure
- 83 kD, Type 1 transmembrane protein
- Distribution
-
Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils
- Function
- Binds single-stranded RNA
- Interaction
- MYD88, TRAF6, IRAK4
- Ligand/Receptor
- Single-stranded GU-rich RNA
- Cell Type
- Dendritic cells, Macrophages, Monocytes, Neutrophils
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
-
- Lood C, et al. 2017. J Exp Med. 214:2103.
- Prinz N, et al. 2011. Blood. 118:2322.
- Gringhuis SI, et al. 2010. Nat Immunol. 11419.
- Cros J, et al. 2010. Immunity. 33:375.
- Peng G, et al. 2005. Science. 309:1380.
- Gene ID
- 51311 View all products for this Gene ID
- UniProt
- View information about CD288 on UniProt.org
Other Formats
View All CD288 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD288 (TLR8) | S16018A | ICFC |
PE anti-human CD288 (TLR8) | S16018A | ICFC |
APC anti-human CD288 (TLR8) | S16018A | ICFC |
FITC anti-human CD288 (TLR8) | S16018A | ICFC |
Brilliant Violet 421™ anti-human CD288 (TLR8) | S16018A | ICFC |
PerCP/Cyanine5.5 anti-human CD288 (TLR8) | S16018A | ICFC |
PE/Cyanine7 anti-human CD288 (TLR8) | S16018A | ICFC |
APC/Fire™ 750 anti-human CD288 (TLR8) | S16018A | ICFC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Paci... -
PE anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Bril... -
APC anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 Bril... -
FITC anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 APC,... -
Brilliant Violet 421™ anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with CD14 APC,... -
PerCP/Cyanine5.5 anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with anti-huma... -
PE/Cyanine7 anti-human CD288 (TLR8)
Human peripheral blood monocytes stained with anti-human CD1... -
APC/Fire™ 750 anti-human CD288 (TLR8)
Human peripheral blood monocytes were stained with anti-huma...
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