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APC anti-human CD305 Recombinant Antibody

Pricing & Availability
Clone
QA19A19 (See other available formats)
Regulatory Status
RUO
Other Names
LAIR-1 (Leukocyte-associated Ig-like receptor 1)
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA19A19_APC_CD305_Antibody_1_120224
Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) Brilliant Violet 421™ and anti-human CD305 recombinant (clone QA19A19) APC (left) or mouse IgG1, κ APC isotype control (right).
  • QA19A19_APC_CD305_Antibody_1_120224
    Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) Brilliant Violet 421™ and anti-human CD305 recombinant (clone QA19A19) APC (left) or mouse IgG1, κ APC isotype control (right).
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332705 25 tests $190
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332706 100 tests $379
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Description

CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone QA19A19 can completely block the binding of clone NKTA255 on target cells.

Antigen Details

Structure
40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
Distribution

Expressed on epithelial and mesothelial cells

Function
NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
Interaction
Human
Ligand/Receptor
Collagens
Cell Type
B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
Biology Area
Immunology, Inhibitory Molecules, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Meyaard L, et al. 2008. J Leukoc Biol. 83:799-803.
  2. Lebbink RJ, et al. 2006. J Exp Med. 203:1419-25.
Gene ID
3903 View all products for this Gene ID
UniProt
View information about CD305 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/27/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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