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APC anti-human IL-27Rα Antibody

Pricing & Availability
Clone
W16093B (See other available formats)
Regulatory Status
RUO
Other Names
IL-27RA, WSX-1, TCCR
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
W16093B_APC_IL-27Ra_Antibody_031623
Human peripheral blood lymphocytes were stained with anti-human CD4 Brilliant Violet 421™ and anti-human IL-27Rα (clone W16093B) APC (left) or mouse IgG1, κ APC isotype control (right).
  • W16093B_APC_IL-27Ra_Antibody_031623
    Human peripheral blood lymphocytes were stained with anti-human CD4 Brilliant Violet 421™ and anti-human IL-27Rα (clone W16093B) APC (left) or mouse IgG1, κ APC isotype control (right).
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384607 25 tests $196
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384608 100 tests $409
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Description

69 kD glycosylated transmembrane subunit of IL-27 receptor complex consisting of IL27Ra (WSX-1, TCCR) and gp130 (CD130). Expressed on T cells, monocytes, and neutrophils and aside from its effect on innate immunity, is involved in dampening the extent of Th1 immune response post infection. Activity levels of IFN-γ and IL-17 producing T cells are regulated through this receptor which relays signal through Jak-STAT pathway.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human IL-27Rα transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2936771 (BioLegend Cat. No. 384607)
AB_2936771 (BioLegend Cat. No. 384608)

Antigen Details

Distribution

T cells, B cells, monocytes

Function
γ
Interaction
STAT1
Ligand/Receptor
IL27Ra combines with gp130 to form a receptor complex whose activation by IL-27 leads to differing pathway-dependent effector activities.
Cell Type
Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
Cytokines/Chemokines
Antigen References
  1. Takeda A, et al. 2003. J Immunol. 170:4886-90.
  2. Yoshida H and Hunter CA. 2015. Annu Rev Immunol. 33:417-43.
  3. Iwasaki Y, et al. 2015. Int J Mol Sci. 16:2851-63.
Gene ID
9466 View all products for this Gene ID
UniProt
View information about IL-27Ralpha on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/16/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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