- Clone
- CPTC-Gelsolin-2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GSN, AGEL, Actin-depolymerizing factor, ADF, Brevin, Epididymis Secretory Sperm Binding Protein, Amyloidosis, Finnish Type
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
866505 | 25 µg | $129 | ||||
866506 | 100 µg | $300 |
After severing, gelsolin remains bound to the barbed end of the actin filament, preventing the reannealing of severed filaments. Gelsolin is crucial for the maintenance of actin homeostasis. Cells from gelsolin null mice exhibit a variety of defects, such as pronounced stress fibers formation, defective chemotaxis, and wound healing. Dysfunction of Gelsolin has been indicated in multiple diseases include cancer, infection, inflammation, cardiac injury, pulmonary disease, and neurodegeneration. Gelsolin is proteolytically cleaved and rendered inactive in Alzheimer’s disease (AD). Overexpression of gelsolin significantly reduces amyloid beta load in brains of AD transgenic mice.
Product DetailsProduct Details
- Verified Reactivity
- Human, Drosophila
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant full-length gelsolin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
ICC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.5 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2892493 (BioLegend Cat. No. 866505)
AB_2892493 (BioLegend Cat. No. 866506)
Antigen Details
- Structure
- Human gelsolin is a 782 amino acid protein with a molecular mass of 86 kD.
- Distribution
-
Tissue distribution: Central nervous system, phagocytic cells, platelets, fibroblasts, non-muscle cells, smooth and skeletal muscle cells.
Cellular distribution: Cytoskeleton and extracellular - Function
- Gelsolin is a calcium-binding, actin-modulating protein. It can promote the assembly of actin monomers into filaments as well as sever actin filaments.
- Interaction
- Interacts with actin and fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.
- Cell Type
- Astrocytes, Microglia, Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Cell Structure, Neurodegeneration, Neuroscience
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
-
- Ji L, et al. 2015. J Alzheimers Dis. 44(1):13-25
- Asch HL, et al. 1996. Cancer Res. 56(21):4841-5.
- Sun HQ, et al. 1999. J Biol Chem. 274(47):33179-82.
- Ji L, et al. 2009. J Alzheimers Dis. 18(1):105-11.
- Gene ID
- 2934 View all products for this Gene ID
- UniProt
- View information about Gelsolin on UniProt.org
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other Formats
View All Gelsolin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Gelsolin | CPTC-Gelsolin-2 | WB,IHC-P,ICC |
Biotin anti-Gelsolin | CPTC-Gelsolin-2 | ICC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Gelsolin
Western blot of purified anti-Gelsolin antibody (clone CPTC-... Western blot of purified anti-Gelsolin antibody (clone CPTC-... IHC staining of purified anti-Gelsolin antibody (clone CPTC-... IHC staining of purified anti-Gelsolin antibody (clone CPTC-... ICC staining of purified anti-Gelsolin antibody (CPTC-Gelsol... -
Biotin anti-Gelsolin
ICC staining of Biotin anti-Gelsolin antibody (clone CPTC-Ge... ICC staining of Biotin anti-Gelsolin antibody (clone CPTC-Ge... ICC staining of Biotin anti-Gelsolin antibody (clone CPTC-Ge...
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