FITC anti-human CD123 Recombinant Antibody, CD123, QA18A25

Pricing & Availability

Clone: QA18A25 (See other available formats)
Regulatory Status: RUO
Other Names: IL-3Rα, IL-3 Receptor alpha
Isotype: Mouse IgG1, κ
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Product Citations: publications

QA18A25_FITC_CD123_Antibody_053123 — Human peripheral blood lymphocytes were stained with anti-human CD45RO APC and anti-human CD123 recombinant (clone QA18A25) FITC (left) or mouse IgG1, κ FITC isotype control (right).

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365405

25 tests

$75

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365406

100 tests

$150

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Description

CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)
Application Notes: Clone QA18A25 can completely block the binding of clone 6H6 on target cells.
RRID: AB_2941539 (BioLegend Cat. No. 365405)
AB_2941539 (BioLegend Cat. No. 365406)

Antigen Details

Structure: Ig superfamily, type I transmembrane glycoprotein, associates with CDw131, 70 kD
Distribution: Myeloid precursors, basophils, mast cells, macrophages, dendritic cells, megakaryocytes, subset of lymphocytes
Function: Hematopoietic cell proliferation, differentiation
Interaction: Basophils, Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, Macrophages, Mast cells, Megakaryocytes
Ligand/Receptor: IL-3
Cell Type: Antigen-presenting cells, B cells, Basophils, Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, Macrophages, Mast cells, Megakaryocytes
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: Miyajima A, et al. 1993. Blood. 82:1960.
Gene ID: 3563 View all products for this Gene ID
UniProt: View information about CD123 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD123 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD123 Recombinant Antibody	QA18A25	FC
PE/Cyanine7 anti-human CD123 Recombinant Antibody	QA18A25	FC
FITC anti-human CD123 Recombinant Antibody	QA18A25	FC
PE anti-human CD123 Recombinant Antibody	QA18A25	FC
APC anti-human CD123 Recombinant Antibody	QA18A25	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 05/31/2023

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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