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- Clone
- W18077D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- R7, M241, BDCA-1, CD1
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human CD19 APC and anti-human CD1c (clone W18077D) PE (left), or rat IgG2a, κ PE isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 389403 | 25 tests | $120 | ||||
| 389404 | 100 tests | $260 | ||||
CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- RBL1 cells expressing 1-328
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_3097364 (BioLegend Cat. No. 389403)
AB_3097364 (BioLegend Cat. No. 389404)
Antigen Details
- Structure
- 3 kD, Ig superfamily, MHC I-like molecule, associates with β2-microglobulin
- Distribution
-
B cell subset, cortical thymocytes, dendritic cells, and Langerhans cells
- Function
- Presents lipid antigen to CD1c-restricted T cells
- Interaction
- Expressed on B cells in lymph nodes, spleen, and blood
- Ligand/Receptor
- CD1c-restricted TCR
- Cell Type
- B cells, Dendritic cells, Langerhans cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Gene ID
- 911 View all products for this Gene ID
- UniProt
- View information about CD1c on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD1c Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD1c | W18077D | FC |
| PE anti-human CD1c | W18077D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD1c
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human CD1c
Human peripheral blood lymphocytes were stained with anti-hu...
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