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PE anti-human CD252 (OX40L) Antibody

Pricing & Availability
Clone
11C3.1 (See other available formats)
Regulatory Status
RUO
Other Names
Gp34, OX40L, CD134L, CD252, TNFSF4
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
11C3_PE_020708
GM-CSF-stimulated human peripheral blood monocytes (day-3) stained with 11C3.1 PE
  • 11C3_PE_020708
    GM-CSF-stimulated human peripheral blood monocytes (day-3) stained with 11C3.1 PE
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326307 25 tests $146
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326308 100 tests $317
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Description

OX40 ligand (OX40L) is a 35 kD type II transmembrane protein which belongs to TNF superfamily, also known as gp34, CD252, CD134L or TNFSF4. The OX40 ligand is expressed on activated B cells, activated endothelial cells, mature dendritic cells, activated CTLs, activated mast cells, and airway smooth muscle cells. OX40 ligand interacts with OX40 antigen (CD134) expressed predominantly on activated T cells to regulate T cell proliferation and differentiation, and to enhance immunoglobulin secretion by activated B cells.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Castellanos JG et al. 2018. Immunity. 49(6):1077-1089 . PubMed
  2. Gajdasik DW, et al. 2020. Nat Commun. 2.834027778. PubMed
  3. Liang Y, et al. 2019. J Allergy Clin Immunol. 144:1025. PubMed
  4. Guo M, et al. 2021. Front Oncol. 11:632540. PubMed
  5. Valenzuela NM, et al. 2021. Front Immunol. 12:648946. PubMed
  6. Halim TYF et al. 2018. Immunity. 48(6):1195-1207 . PubMed
RRID
AB_2207272 (BioLegend Cat. No. 326307)
AB_2207272 (BioLegend Cat. No. 326308)

Antigen Details

Structure
NGF/TNF superfamily, 35 kD
Distribution

Activated B cells, activated endothelial cells, mature dendritic cells, airway smooth muscle cells

Function
B-cell/T-cell interaction, costimulation
Ligand/Receptor
OX40 (CD134)
Cell Type
B cells, Dendritic cells, Endothelial cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Imura A, et al. 1996. J. Exp. Med. 183:2185.
2. Ohshima Y, et al. 1997. J. Immunol. 159:3838.
3. Ito T, et al. 2005. J. Exp.Med. 202:1213.
4. Ito T, et al. 2006. Proc. Natl. Acad.Sci. USA. 103:13138.

Gene ID
7292 View all products for this Gene ID
UniProt
View information about CD252 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08/11/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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