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PE anti-human CD352 (NTB-A) Antibody

Pricing & Availability
Clone
W19035D (See other available formats)
Regulatory Status
RUO
Other Names
SLAMF6, LY108, TCOM, SF2000, NTBA
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W19035D_PE_CD352_Antibody_011221
Human peripheral blood lymphocytes were surface stained with CD352 (NTB-A) (clone W19035D) PE (filled histogram) or rat IgG2a, k PE isotype control (open histogram).
  • W19035D_PE_CD352_Antibody_011221
    Human peripheral blood lymphocytes were surface stained with CD352 (NTB-A) (clone W19035D) PE (filled histogram) or rat IgG2a, k PE isotype control (open histogram).
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332303 25 tests $122
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332304 100 tests $287
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Description

NTBA (NK-, T-, and B-cell Antigen) is a 60 kD type I transmembrane glycoprotein. It is a member of Ig superfamily belonging to CD2/CD150 subfamily, also known as SLAMF6 (SLAM family member 6), LY108, TCOM, or SF2000. This antigen is expressed on NK cells, T cells (upregulated upon activation), and B cells. NTBA is its own ligand. The homophilic interaction of NTBA is involved in the induction of NK cytotoxicity, CD28 independent T cell costimulation, triggering Th1 cytokines production, and regulation of B cell tolerance. It may play a role in the regulation of autoimmune diseases.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant human CD352 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC-  Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2890763 (BioLegend Cat. No. 332303)
AB_2890763 (BioLegend Cat. No. 332304)

Antigen Details

Structure
Type I transmembrane tyrosine-phosphorylated glycoprotein, CD2/CD150 subfamily, 60 kD
Distribution

NK cells, T cells, B cells

Function
CD28 independent T cell costimulation, induction of NK cell cytotoxicity, regulation of B cell tolerance
Ligand/Receptor
NTBA
Antigen References

1. Yigit B, et al. 2019. Cancer Immunol. Res. 10.1158/2326-6066
2. Wu N, et al. 2016. Nature Immunol. 17, 387-396
3. Radomir L, et al. 2017. J. Immunol. 199(8) 2745-2757

 

Gene ID
114836 View all products for this Gene ID
UniProt
View information about CD352 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 12/01/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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