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PE anti-mouse CD202b (Tie-2, CD202) Antibody

Pricing & Availability
Clone
TEK4 (See other available formats)
Regulatory Status
RUO
Other Names
Tie-2, TEK
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
TEK4_PE_070609.jpg
BEND.3, mouse endothelial cells stained with TEK4 PE
  • TEK4_PE_070609.jpg
    BEND.3, mouse endothelial cells stained with TEK4 PE
  • TEK4_PE_1_072811
    Ly-6G and B220 double negative C57BL/6 mouse bone marrow cells were stained with CD117 APC and CD202b (clone TEK4) PE (top) or rat IgG1, κ PE isotype control (bottom).
  • TEK4_PE_2_072811
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Cat # Size Price Quantity Check Availability Save
124007 50 µg $134
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124008 200 µg $360
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Description

CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
  2. Sanchez-Martin L, et al. 2011. Blood 117:88. PubMed
Product Citations
  1. Kalgudde Gopal S, et al. 2023. Nat Commun. 14:3020. PubMed
  2. Malecová B, et al. 2018. Nat Commun. 2.923611111. PubMed
  3. Michael I, et al. 2017. BMC Cancer. 10.1186/s12885-017-3531-y. PubMed
  4. Beazley–Long N, et al. 2018. Brain Behav Immun. 3.117361111. PubMed
  5. Evans R, et al. 2019. Cell Rep. 27:1967. PubMed
  6. Tao HC, et al. 2020. Front Immunol. 11:148. PubMed
  7. Liu X, et al. 2013. Invest Ophthalmol Vis Sci . 54:7386. PubMed
  8. Carrer A, et al. 2012. Cancer Res. 72:6371. PubMed
RRID
AB_2271789 (BioLegend Cat. No. 124007)
AB_2271789 (BioLegend Cat. No. 124008)

Antigen Details

Structure
The receptor tyrosine kinase (RTK) family
Distribution

Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes

Cell Type
Endothelial cells, Epithelial cells, T cells
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
2. Yano M, et al. 1997. Blood 89:431726.
3. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:1206.

Gene ID
21687 View all products for this Gene ID
UniProt
View information about CD202b on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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