- Clone
- HMJ2-1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- HJ2, Jagged2, Jagged-2 precursor, JAG2
- Isotype
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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131007 | 50 µg | $183 |
The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Jagged-2 is one of the several Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. Jagged-2 is reported to be essential for the regulation of spermatogenesis.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- CHO cells expressing murine Jagged-2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Moriyama Y, et al. 2008. Int. Immunol. 20:763 (FC)
- Product Citations
-
- RRID
-
AB_2128358 (BioLegend Cat. No. 131007)
Antigen Details
- Structure
- A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). After a single transmembrane domain (TM) is a short in
- Distribution
- Testicular tissues and spermatids
- Function
- The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect the target cells. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate.
- Ligand/Receptor
- Notch receptors
- Cell Targets
- Skeletrophin binds the intracellular regions of Jagged-2, but not those of Delta-1,3,4, or Jagged-1.
- Biology Area
- Immunology
- Antigen References
-
1. Ehebauer MT, et al. 2006. Biochem J 392:13
2. Shimizu K, et al. 2000. Mol Cell Biology 20:18
3. Hellstrom M, et al. 2007. Nature 445:776
4. Luo B, et al. 1997. Mol Cell Biol. 17:6057 - Gene ID
- 16450 View all products for this Gene ID
- UniProt
- View information about Jagged 2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All Jagged 2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse Jagged 2 | HMJ2-1 | FC,IHC |
PE anti-mouse Jagged 2 | HMJ2-1 | FC |
TotalSeq™-B1022 anti-mouse Jagged 2 | HMJ2-1 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-mouse Jagged 2
FJ2/CHO transfectant cell line stained with HMJ2-1 purified,... -
PE anti-mouse Jagged 2
FJ2/CHO transfected cells stained with HMJ2-1 PE -
TotalSeq™-B1022 anti-mouse Jagged 2
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