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- Clone
- MIH47 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TREML2, TREM-like transcript 2
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Mouse TLT-2 transfected cells stained with MIH47 PE -
C57BL/6 mouse splenocytes stained with MIH47
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 136603 | 50 µg | $146 | ||||
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2, TREML2) is a type I transmembrane protein in TREM family. It consists of a single extracellular Ig-like domain of the V-type, a transmembrane domain, and a short cytoplasmic domain. TLT-2 is expressed on myeloid , B cells , and macrophages. It was also found to express on CD8+ T cells and activated CD4+ T cells. It regulates innate immune response based on its expression profile, costimulates the activation of T cells. Transduction of TLT-2 into T cells resulted in enhanced IL-2 and IFN-gamma production. It was reported that B3-H7 is a receptor of TLT-2. Blockade of the B7-H3/ TLT-2 pathway with monoclonal antibodies against B7-H3 or TLT-2 efficiently inhibited hypersensitivity response. Further studies are needed to confirm the ligand.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse TLT-2 Ig fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Hashiguchi M, et al. 2008. Proc. Nat. Acad. Sci. U. S. A. 105(30):10495
- RRID
-
AB_2208701 (BioLegend Cat. No. 136603)
Antigen Details
- Structure
- A type I transmembrane protein in TREM family, consists of a single extracellular Ig-like domain of the V-type, a transmembrane domain, and a short cytoplasmic domain.
- Distribution
- Expressed on myeloid cells, B cells, macrophages, CD8+ T cells, and activated CD4+ T cells.
- Function
- Regulate innate immune response, IL-2, IFN-gamma production, and hypersensitivity response.
- Cell Type
- B cells, Macrophages, T cells
- Biology Area
- Immunology, Innate Immunity
- Antigen References
-
1. King RG, et al. 2006. J. Immunol. 176:6012
2. Ford JW, et al. 2009. Curr Opin Immunol. 21(1):38
3. Leitner J, et al. 2009. Eur. J. Immunol. 39(7):1754 - Gene ID
- 328833 View all products for this Gene ID
- UniProt
- View information about TLT-2 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All TLT-2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse TLT-2 | MIH47 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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