- Clone
- F38P7H9 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- PURH, IMPCHASE/AICARFT, Bifunctional purine biosynthesis protein PURH
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
635602 | 100 µg | $229 |
ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, frog and fruit fly ATIC.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- Mouse, Rat, Frog, Drosophila
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Ovalbumin-conjugated synthetic Peptide AHTNLRLFHH
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
KO/KD-WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5-10 µg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2227799 (BioLegend Cat. No. 635602)
Antigen Details
- Structure
- Belongs to the purH family, the IMP cyclohydrolase activity resides in the N-terminal region. Predicted molecular weight approximately 65 kD.
- Distribution
-
Cytoplasm
- Function
- ATIC catalyzes the penultimate and final steps in the de novo purine biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP.
- Interaction
- CDK2, Stomatin, JAK1, NM23B, IKKE, HNRNP, CIA30
- Biology Area
- Cell Biology
- Antigen References
-
1. Rayl EA, et al. 1996. J. Biol. Chem. 271:2225
- Gene ID
- 471 View all products for this Gene ID
- UniProt
- View information about ATIC on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All ATIC Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-ATIC | F38P7H9 | WB |
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Purified anti-ATIC
Total lysates (15 µg protein) from 293T and 293T/ATIC CRISPR...
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