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Purified anti-Caldesmon Antibody

Pricing & Availability
Clone
BSB-19 (See other available formats)
Regulatory Status
RUO
Other Names
CDM, CALD1
Isotype
Mouse IgG1, κ
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Product Citations
publications
BSBdash19_PURE_Caldesmon_Antibody_IHCP_080216
IHC staining of anti-Caldesmon antibody (clone BSB-19) on formalin-fixed paraffin-embedded human uterus tissue. Following antigen retrieval using sodium citrate, the tissue was incubated with the primary antibody for one hour at room temperature at 1 µg/ml. BioLegend's Ultra-Streptavidin (USA) HRP Detection Kit was used for detection.
  • BSBdash19_PURE_Caldesmon_Antibody_IHCP_080216
    IHC staining of anti-Caldesmon antibody (clone BSB-19) on formalin-fixed paraffin-embedded human uterus tissue. Following antigen retrieval using sodium citrate, the tissue was incubated with the primary antibody for one hour at room temperature at 1 µg/ml. BioLegend's Ultra-Streptavidin (USA) HRP Detection Kit was used for detection.
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846702 100 µg $288
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Description

Caldesmon is a calmodulin-, actin-, and tropomyosin-binding protein that plays an essential role in smooth muscle and non-muscle contraction. This protein is also involved in cellular mitosis and Schwann cell migration during peripheral nerve regeneration.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Synthetic peptide corresponding to the N-terminus of the human Caldesmon protein.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

IHC-P - Quality tested
IHC-F, WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2629661 (BioLegend Cat. No. 846702)

Antigen Details

Structure
Caldesmon is a 793 amino acid protein with a molecular mass of 93 kD.
Distribution

Tissue distribution: high-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Caldesmon is not expressed in skeletal muscle or heart..
Cellular distribution: cytoskeleton, cytosol, and plasma membrane.

Function
Caldemon mainly regulates actomyosin interactions in smooth muscle and non-muscle cells which affects cell contractions. The protein is also involved in cellular mitosis and in Schwann cell migration during peripheral nerve regeneration.
Interaction
Calmodulin, actin, and tropomyosin.
Biology Area
Cell Biology, Cell Motility/Cytoskeleton/Structure
Molecular Family
Enzymes and Regulators
Antigen References

1. Huber PA. 1997. Int. J. Biochem. Cell Biol. 29(8-9):1047. PubMed
2. Mayanagi T, Sobue K. 2011. Cell. Adh. Migr. 5(2):150. PubMed
3. Wang CL. 2008. Adv. Exp. Med. Biol. 644:250. PubMed
4. Sobue K, Sellers JR. 1991. J. Biol. Chem. 266(19):12115. PubMed

Gene ID
800 View all products for this Gene ID
UniProt
View information about Caldesmon on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 08/04/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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