Purified anti-CD49b (Integrin α2) Antibody (Previously Covance catalog# MMS-488P)

Pricing & Availability
Clone
P1E6 (See other available formats)
Regulatory Status
RUO
Other Names
ITGA2, collagen receptor, VLA-2 subunit alpha, platelet antigen Br, platelet glycoprotein Ia, platelet glycoprotein GPIa, CD49 antigen-like family member B, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 sub
Previously
Covance Catalog# MMS-488P
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
P1E6_Purified_Integrina2b1_Antibody_IHC_030215
Staining of Integrin α2 (P1E6) at 1ug/ml on frozen normal human kidney tissue.
  • P1E6_Purified_Integrina2b1_Antibody_IHC_030215
    Staining of Integrin α2 (P1E6) at 1ug/ml on frozen normal human kidney tissue.
Cat # Size Price Quantity Check Availability Save
910901 100 µL $275
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Description

CD49b is a 170 kD transmembrane protein, also known as α2 integrin, VLA-2 α chain, Integrin α2 and GPIa. It associates with CD29 (β1 integrin) to form VLA-2, a collagen and laminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This monoclonal antibody was generated against human HT1080 fibrosarcoma cells.
Formulation
Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-F - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining.

The optimal working dilution should be determined for each specific assay condition.
IHC: 1:1,000

Tissue: Frozen sections
Pretreatment: None
Incubation: 60 minutes at room temperature
 

Application Notes

This antibody is effective in Immunohistochemistry (IHC).

IHC Positive Control: Normal Human Kidney

This antibody is directed against the a2 subunit. It was subsequently purified using protein G.

Application References

(PubMed link indicates BioLegend citation)
  1. Wayner EA, et al. 2007. Meths. Enzymol. In: Integrins. 426:117.
Product Citations
  1. Wu Y, et al. 2021. Immunity. 54:2595. PubMed
RRID
AB_2565103 (BioLegend Cat. No. 910901)

Antigen Details

Biology Area
Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
Molecular Family
Adhesion Molecules
Gene ID
3673 View all products for this Gene ID
UniProt
View information about CD49b on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 5    Revision Date: 06/10/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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