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Purified anti-Desmoglein 2 Antibody

Pricing & Availability
Clone
8E5 (See other available formats)
Regulatory Status
RUO
Other Names
DSG2
Isotype
Mouse IgG1, κ
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Product Citations
publications
8E5_PURE_Desmoglein2_NPRF_081419
Western blot of purified anti-Desmoglein 2 antibody (clone 8E5). Lane 1: Molecular weight marker; Lane 2: 20 µg of HeLa lysate; Lane 3: 20 µg of SH-SY5Y lysate (Negative). The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • 8E5_PURE_Desmoglein2_NPRF_081419
    Western blot of purified anti-Desmoglein 2 antibody (clone 8E5). Lane 1: Molecular weight marker; Lane 2: 20 µg of HeLa lysate; Lane 3: 20 µg of SH-SY5Y lysate (Negative). The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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869401 25 µg $106
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869402 100 µg $276
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Description

Desmoglein 2 (DSG2) is a calcium-binding adhesion molecule that is highly expressed in epithelial cells and cardiomyocytes in vertebrates. DSG2 mainly locates to the intracellular adhesive junction called desmosome, which is a structure that functions in cell-to-cell adhesion. Clinically, mutations in DSG2 are mostly linked to cardiomyopathy. A recent GWAS study has shown that DSG2 is 1 of the 20 genetic risk factors that are associated with Alzheimer's disease.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2814633 (BioLegend Cat. No. 869401)
AB_2814633 (BioLegend Cat. No. 869402)

Antigen Details

Structure
DSG2 is a 1118 amino acid protein with predicted molecular mass of ~122 kD and observed molecular mass of ~150 kD.
Distribution

Tissue Distribution: Ubiquitously expressed

Cellular Distribution: Plasma membrane

Function
DSG2 is localized to desmosomes and functions in cell-to-cell adhesion.
Interaction
DSG2 is an integral component of desmosomes.
Cell Type
Epithelial cells
Biology Area
Cell Adhesion, Neurodegeneration, Neuroinflammation, Synaptic Biology
Molecular Family
Adhesion Molecules
Antigen References
  1. Kim JH. 2018. Dement Neurocogn Disord. 10.12779/dnd.2018.17.4.131. 
  2. Harrison OJ, et al. 2016. Proc. Natl. Acad. Sci U S A. 113:7160-5. 
Gene ID
1829 View all products for this Gene ID
UniProt
View information about Desmoglein 2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 08/14/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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