- Clone
- 6H5/Gemin6 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Gemin6
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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862301 | 25 µg | $106 | ||||
862302 | 100 µg | $276 |
Gem-associated protein 6 (Gemin 6) is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells. Gemin 6 has been shown to form heterodimers with Gemin 7, and together they bind to unrip and sequester the SMN complex in the cytoplasm for small nuclear ribonucleoproteins (snRNP) assembly3.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone is more reactive to mouse compared to human or rat Gemin 6. The recommended usage concentration for Western blotting in mouse is 0.2 - 1 µg/ml, and in human and rat 5.0 - 10 µg/mL
-
Application References
(PubMed link indicates BioLegend citation) -
- Massenet S, et al. 2002. Mol Cell Biol. 22(18):6533 (WB)
- Battle DJ, et al. 2007. J Biol Chem. 282(38):27953 (IP)
- Product Citations
-
- RRID
-
AB_2810749 (BioLegend Cat. No. 862301)
AB_2810749 (BioLegend Cat. No. 862302)
Antigen Details
- Structure
- Gemin 6 is a 167 amino acid protein with an apparent molecular mass of ~19 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Nucleus and cytosol - Function
- Gemin 6 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.
- Interaction
- Gemin-7, unrip
- Cell Type
- Mature Neurons, Neurons
- Biology Area
- Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience
- Molecular Family
- Nuclear Markers
- Antigen References
-
- Lanfranco M, et al. 2017. FEBS Lett. 591(21):3600
- Massenet S, et al. 2002. Mol Cell Biol. 22(18):6533
- Battle DJ, et al. 2007. J Biol Chem. 282(38):27953
- Gene ID
- 79833 View all products for this Gene ID
- UniProt
- View information about Gemin 6 on UniProt.org
Related FAQs
Other Formats
View All Gemin 6 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Gemin 6 | 6H5/Gemin6 | WB |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Gemin 6
Western blot of purified anti-Gemin 6 antibody (clone 6H5/Ge...
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